Identity
HGNC
LOCATION
17p13.1
LOCUSID
ALIAS
EIF-5A,EIF5A1,eIF-4D,eIF5AI
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 1984
MIM: 600187
HGNC: 3300
Ensembl: ENSG00000132507
Variants:
dbSNP: 1984
ClinVar: 1984
TCGA: ENSG00000132507
COSMIC: EIF5A
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38654332 | 2024 | AMD1 promotes breast cancer aggressiveness via a spermidine-eIF5A hypusination-TCF4 axis. | 2 |
| 38862693 | 2024 | Construction of a nomogram for predicting HNSCC distant metastasis and identification of EIF5A as a hub gene. | 0 |
| 38654332 | 2024 | AMD1 promotes breast cancer aggressiveness via a spermidine-eIF5A hypusination-TCF4 axis. | 2 |
| 38862693 | 2024 | Construction of a nomogram for predicting HNSCC distant metastasis and identification of EIF5A as a hub gene. | 0 |
| 36766751 | 2023 | Renal Ischemia Tolerance Mediated by eIF5A Hypusination Inhibition Is Regulated by a Specific Modulation of the Endoplasmic Reticulum Stress. | 1 |
| 36893894 | 2023 | Combined inhibition of polyamine metabolism and eIF5A hypusination suppresses colorectal cancer growth through a converging effect on MYC translation. | 7 |
| 36973244 | 2023 | Cryo-EM structure of human eIF5A-DHS complex reveals the molecular basis of hypusination-associated neurodegenerative disorders. | 3 |
| 37047039 | 2023 | Comparison of Human Eukaryotic Translation Initiation Factors 5A1 and 5AL1: Identification of Amino Acid Residues Important for EIF5A1 Lysine 50 Hypusination and Its Protein Stability. | 1 |
| 37137790 | 2023 | High levels of hypusinated eIF5A in leiomyoma and leiomyosarcoma pathologies: a possible novel therapeutic target. | 2 |
| 37219665 | 2023 | Inhibiting eukaryotic initiation factor 5A (eIF5A) hypusination attenuated activation of the SIK2 (salt-inducible kinase 2)-p4E-BP1 pathway involved in ovarian cancer cell proliferation and migration. | 2 |
| 37333770 | 2023 | Deoxyhypusine synthase mutations alter the post-translational modification of eukaryotic initiation factor 5A resulting in impaired human and mouse neural homeostasis. | 1 |
| 37653021 | 2023 | Targeted inhibition of eIF5A(hpu) suppresses tumor growth and polarization of M2-like tumor-associated macrophages in oral cancer. | 5 |
| 37743008 | 2023 | Exosomal EIF5A derived from Lewis lung carcinoma induced adipocyte wasting in cancer cachexia. | 1 |
| 36766751 | 2023 | Renal Ischemia Tolerance Mediated by eIF5A Hypusination Inhibition Is Regulated by a Specific Modulation of the Endoplasmic Reticulum Stress. | 1 |
| 36893894 | 2023 | Combined inhibition of polyamine metabolism and eIF5A hypusination suppresses colorectal cancer growth through a converging effect on MYC translation. | 7 |
Citation
Dessen P
EIF5A (eukaryotic translation initiation factor 5A)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/43812/eif5a
