FUT3 (fucosyltransferase 3 (Lewis blood group))

2007-02-01  

Identity

HGNC
LOCATION
19p13.3
LOCUSID
ALIAS
CD174,FT3B,FucT-III,LE,Les
FUSION GENES

Other Information

Locus ID:

NCBI: 2525
MIM: 111100
HGNC: 4014
Ensembl: ENSG00000171124

Variants:

dbSNP: 2525
ClinVar: 2525
TCGA: ENSG00000171124
COSMIC: FUT3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000171124ENST00000303225P21217
ENSG00000171124ENST00000458379P21217
ENSG00000171124ENST00000585715K7EQ20
ENSG00000171124ENST00000587048K7ES24
ENSG00000171124ENST00000589620P21217
ENSG00000171124ENST00000589714K7ENT3
ENSG00000171124ENST00000589918P21217

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Glycosphingolipid biosynthesis - lacto and neolacto seriesKEGGko00601
Glycosphingolipid biosynthesis - lacto and neolacto seriesKEGGhsa00601
Metabolic pathwaysKEGGhsa01100
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Transport to the Golgi and subsequent modificationREACTOMER-HSA-948021
N-glycan antennae elongation in the medial/trans-GolgiREACTOMER-HSA-975576
Reactions specific to the complex N-glycan synthesis pathwayREACTOMER-HSA-975578

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
373420602023Relationship between ABO Blood Group Alleles and Pancreatic Cancer Is Modulated by Secretor (FUT2) Genotype, but Not Lewis Antigen (FUT3) Genotype.0
379461302023FUT3 facilitates glucose metabolism of lung adenocarcinoma via activation of NF-κB pathway.1
373420602023Relationship between ABO Blood Group Alleles and Pancreatic Cancer Is Modulated by Secretor (FUT2) Genotype, but Not Lewis Antigen (FUT3) Genotype.0
379461302023FUT3 facilitates glucose metabolism of lung adenocarcinoma via activation of NF-κB pathway.1
341560942022Estimation of Lewis-negative alleles by high-resolution melting analysis of three tag SNPs of FUT3.1
349368452022Correlations of FUT3 gene polymorphisms with colon polyps.1
363352652022Maternal and child FUT2 and FUT3 status demonstrate relationship with gut health, body composition and growth of children in Bangladesh.0
341560942022Estimation of Lewis-negative alleles by high-resolution melting analysis of three tag SNPs of FUT3.1
349368452022Correlations of FUT3 gene polymorphisms with colon polyps.1
363352652022Maternal and child FUT2 and FUT3 status demonstrate relationship with gut health, body composition and growth of children in Bangladesh.0
333019832021Estimation of genetic variation in the Secretor and Lewis genes in Iranian hospitalized children.2
333019832021Estimation of genetic variation in the Secretor and Lewis genes in Iranian hospitalized children.2
320628222020High FUT3 expression is a marker of lower overall survival of breast cancer patients.9
321652422020Norovirus infection and HBGA host genetic susceptibility in a birth community-cohort, Rio de Janeiro, Brazil.6
322184792020Systematic sequence analysis of the FUT3 gene identifies 11 novel alleles in the Sindhi and Punjabi populations from Pakistan.3

Citation

Dessen P

FUT3 (fucosyltransferase 3 (Lewis blood group))

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43830/fut3