PDE4D (phosphodiesterase 4D)

2007-02-01  

Identity

HGNC
PDE4D
LOCATION
5q11.2
LOCUSID
5144
ALIAS
ACRDYS2,DPDE3,HSPDE4D,PDE43,PDE4DN2,STRK1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5144
MIM: 600129
HGNC: 8783
Ensembl: ENSG00000113448

Variants:

dbSNP: 5144
ClinVar: 5144
TCGA: ENSG00000113448
COSMIC: PDE4D

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000113448ENST00000309641Q08499
ENSG00000113448ENST00000317118Q08499
ENSG00000113448ENST00000340635Q08499
ENSG00000113448ENST00000340635A0A140VJR0
ENSG00000113448ENST00000358923Q08499
ENSG00000113448ENST00000360047Q08499
ENSG00000113448ENST00000405755Q08499
ENSG00000113448ENST00000502484Q08499
ENSG00000113448ENST00000502575Q08499
ENSG00000113448ENST00000503258Q08499
ENSG00000113448ENST00000505453D6RHE0
ENSG00000113448ENST00000505507D6RIG1
ENSG00000113448ENST00000507116Q08499
ENSG00000113448ENST00000509368D6R9L4
ENSG00000113448ENST00000514552D6RAQ0
ENSG00000113448ENST00000515835D6RBB2
ENSG00000113448ENST00000546160A0A087WSZ7
ENSG00000113448ENST00000636120A0A1B0GW84
ENSG00000113448ENST00000638939A0A1W2PQN6

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Purine metabolismKEGGko00230
Purine metabolismKEGGhsa00230
Morphine addictionKEGGhsa05032
Morphine addictionKEGGko05032
cAMP signaling pathwayKEGGhsa04024
cAMP signaling pathwayKEGGko04024
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555
Opioid SignallingREACTOMER-HSA-111885
DARPP-32 eventsREACTOMER-HSA-180024

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA151249535diureticsChemicalClinicalAnnotationassociatedPD23778321
PA445086NephrosclerosisDiseaseClinicalAnnotationassociatedPD23778321
PA447216SchizophreniaDiseaseClinicalAnnotationassociatedPD
PA451201quetiapineChemicalClinicalAnnotationassociatedPD
PA59ARRB1GenePathwayassociated
PA60ARRB2GenePathwayassociated

References

Pubmed IDYearTitleCitations
381727092024PDE4D single nucleotide polymorphism rs918592 is associated with ischemic Stroke risk in Chinese populations: a meta-analysis.0
383191572024GNAS mutation inhibits growth and induces phosphodiesterase 4D expression in colorectal cancer cell lines.0
381727092024PDE4D single nucleotide polymorphism rs918592 is associated with ischemic Stroke risk in Chinese populations: a meta-analysis.0
383191572024GNAS mutation inhibits growth and induces phosphodiesterase 4D expression in colorectal cancer cell lines.0
368623032023Phosphodiesterase 4 D (PDE4D) gene polymorphisms and risk of ischemic stroke: A systematic review and meta-analysis.0
374275862023Inhibition of phosphodiesterase 4D suppresses mTORC1 signaling and pancreatic cancer growth.4
375494682023PDE4D gene variants and haplotypes are associated with asthma and atopy in Brazilian children.0
379941452023[Research progress on genetic variants of PDE4D and susceptibility to stroke in Chinese population].0
382724842023Association of the PDE4D gene variant with selected markers in individuals with ischaemic heart disease: a pilot study.0
368623032023Phosphodiesterase 4 D (PDE4D) gene polymorphisms and risk of ischemic stroke: A systematic review and meta-analysis.0
374275862023Inhibition of phosphodiesterase 4D suppresses mTORC1 signaling and pancreatic cancer growth.4
375494682023PDE4D gene variants and haplotypes are associated with asthma and atopy in Brazilian children.0
379941452023[Research progress on genetic variants of PDE4D and susceptibility to stroke in Chinese population].0
382724842023Association of the PDE4D gene variant with selected markers in individuals with ischaemic heart disease: a pilot study.0
354203102022Association of plaque enhancement on vessel wall MRI and the phosphodiesterase 4D variant with stroke recurrence in patients with symptomatic intracranial atherosclerosis.3

Citation

Dessen P

PDE4D (phosphodiesterase 4D)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43832/css/lib/img/deep-insight-explorer/