Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 4668
MIM: 104170
HGNC: 7631
Ensembl: ENSG00000198951
Variants:
dbSNP: 4668
ClinVar: 4668
TCGA: ENSG00000198951
COSMIC: NAGA
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Glycosphingolipid biosynthesis - globo and isoglobo series | KEGG | hsa00603 |
| Lysosome | KEGG | ko04142 |
| Lysosome | KEGG | hsa04142 |
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA443450 | Asthma | Disease | Literature, MultilinkAnnotation | associated | 24934276 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 35521802 | 2023 | Could low α-N-acetylgalactosaminidase plasma concentration cause schizophrenia? | 2 |
| 35521802 | 2023 | Could low α-N-acetylgalactosaminidase plasma concentration cause schizophrenia? | 2 |
| 34816536 | 2022 | Silencing of α-N-acetylgalactosaminidase in the gastric cancer cells amplified cell death and attenuated migration, while the multidrug resistance remained unchanged. | 1 |
| 34816536 | 2022 | Silencing of α-N-acetylgalactosaminidase in the gastric cancer cells amplified cell death and attenuated migration, while the multidrug resistance remained unchanged. | 1 |
| 33931730 | 2021 | A missense variant in NDUFA6 confers schizophrenia risk by affecting YY1 binding and NAGA expression. | 13 |
| 33931730 | 2021 | A missense variant in NDUFA6 confers schizophrenia risk by affecting YY1 binding and NAGA expression. | 13 |
| 31468281 | 2020 | A Novel Homozygous Missense Variant in the NAGA Gene with Extreme Intrafamilial Phenotypic Heterogeneity. | 2 |
| 31468281 | 2020 | A Novel Homozygous Missense Variant in the NAGA Gene with Extreme Intrafamilial Phenotypic Heterogeneity. | 2 |
| 24934276 | 2014 | A genome-wide survey of CD4(+) lymphocyte regulatory genetic variants identifies novel asthma genes. | 29 |
| 24934276 | 2014 | A genome-wide survey of CD4(+) lymphocyte regulatory genetic variants identifies novel asthma genes. | 29 |
| 20444686 | 2010 | Interconversion of the specificities of human lysosomal enzymes associated with Fabry and Schindler diseases. | 9 |
| 20444686 | 2010 | Interconversion of the specificities of human lysosomal enzymes associated with Fabry and Schindler diseases. | 9 |
| 19394758 | 2009 | Serum proteomic profile of cutaneous malignant melanoma and relation to cancer progression: association to tumor derived alpha-N-acetylgalactosaminidase activity. | 18 |
| 19683538 | 2009 | The 1.9 a structure of human alpha-N-acetylgalactosaminidase: The molecular basis of Schindler and Kanzaki diseases. | 19 |
| 19853240 | 2009 | Use of a modified alpha-N-acetylgalactosaminidase in the development of enzyme replacement therapy for Fabry disease. | 19 |
Citation
Dessen P
NAGA (alpha-N-acetylgalactosaminidase)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/43833/naga
