Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 5737
MIM: 600563
HGNC: 9600
Ensembl: ENSG00000122420
Variants:
dbSNP: 5737
ClinVar: 5737
TCGA: ENSG00000122420
COSMIC: PTGFR
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000122420 | ENST00000370756 | P43088 |
| ENSG00000122420 | ENST00000370757 | P43088 |
| ENSG00000122420 | ENST00000370758 | P43088 |
| ENSG00000122420 | ENST00000497923 | F2Z2Z6 |
Expression (GTEx)
Pathways
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA164774763 | latanoprost | Chemical | ClinicalAnnotation | associated | PD | 17467803, 25339146, 27336732 | |
| PA444282 | Glaucoma, Open-Angle | Disease | ClinicalAnnotation | associated | PD | 17467803, 25339146, 27336732 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37160891 | 2023 | Ligand-induced activation and G protein coupling of prostaglandin F(2α) receptor. | 4 |
| 37160891 | 2023 | Ligand-induced activation and G protein coupling of prostaglandin F(2α) receptor. | 4 |
| 34174923 | 2021 | Replicative verification of susceptibility genes previously identified from families with segregating developmental dysplasia of the hip. | 1 |
| 34174923 | 2021 | Replicative verification of susceptibility genes previously identified from families with segregating developmental dysplasia of the hip. | 1 |
| 29773555 | 2018 | Prostaglandin F(2α) Facilitates Hepatic Glucose Production Through CaMKIIγ/p38/FOXO1 Signaling Pathway in Fasting and Obesity. | 25 |
| 29773555 | 2018 | Prostaglandin F(2α) Facilitates Hepatic Glucose Production Through CaMKIIγ/p38/FOXO1 Signaling Pathway in Fasting and Obesity. | 25 |
| 27862086 | 2017 | Correlations of AFAP1, GMDS and PTGFR gene polymorphisms with intra-ocular pressure response to latanoprost in patients with primary open-angle glaucoma. | 8 |
| 28584054 | 2017 | Conformational biosensors reveal allosteric interactions between heterodimeric AT1 angiotensin and prostaglandin F2α receptors. | 12 |
| 27862086 | 2017 | Correlations of AFAP1, GMDS and PTGFR gene polymorphisms with intra-ocular pressure response to latanoprost in patients with primary open-angle glaucoma. | 8 |
| 28584054 | 2017 | Conformational biosensors reveal allosteric interactions between heterodimeric AT1 angiotensin and prostaglandin F2α receptors. | 12 |
| 25339146 | 2015 | Influence of PTGS1, PTGFR, and MRP4 genetic variants on intraocular pressure response to latanoprost in Chinese primary open-angle glaucoma patients. | 8 |
| 25512374 | 2015 | Angiotensin II type I and prostaglandin F2α receptors cooperatively modulate signaling in vascular smooth muscle cells. | 29 |
| 25704319 | 2015 | Association between SNPs of Metalloproteinases and Prostaglandin F2α Receptor Genes and Latanoprost Response in Open-Angle Glaucoma. | 17 |
| 25977569 | 2015 | Rare SNP rs12731181 in the miR-590-3p Target Site of the Prostaglandin F2α Receptor Gene Confers Risk for Essential Hypertension in the Han Chinese Population. | 7 |
| 26170067 | 2015 | 11β-Prostaglandin F2α, a bioactive metabolite catalyzed by AKR1C3, stimulates prostaglandin F receptor and induces slug expression in breast cancer. | 12 |
Citation
Dessen P
PTGFR (prostaglandin F receptor)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/43835/ptgfr
