SRD5A1 (steroid 5 alpha-reductase 1)

2007-02-01  

Identity

HGNC
SRD5A1
LOCATION
5p15.31
LOCUSID
6715
ALIAS
S5AR
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6715
MIM: 184753
HGNC: 11284
Ensembl: ENSG00000145545

Variants:

dbSNP: 6715
ClinVar: 6715
TCGA: ENSG00000145545
COSMIC: SRD5A1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000145545ENST00000274192P18405
ENSG00000145545ENST00000510531D6RDL6
ENSG00000145545ENST00000513117D6RG03

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Steroid hormone biosynthesisKEGGko00140
Steroid hormone biosynthesisKEGGhsa00140
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Metabolism of steroid hormonesREACTOMER-HSA-196071
Androgen biosynthesisREACTOMER-HSA-193048

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
349964472022Epigenetic regulation of 5α reductase-1 underlies adaptive plasticity of reproductive function and pubertal timing.3
349964472022Epigenetic regulation of 5α reductase-1 underlies adaptive plasticity of reproductive function and pubertal timing.3
336276302021Suppression of steroid 5α-reductase type I promotes cellular apoptosis and autophagy via PI3K/Akt/mTOR pathway in multiple myeloma.9
347649402021Steroid Metabolism in Children and Adolescents With Obesity and Insulin Resistance: Altered SRD5A and 20α/20βHSD Activity.5
348857332021Treatment of Benign Prostatic Hyperplasia by Natural Drugs.24
336276302021Suppression of steroid 5α-reductase type I promotes cellular apoptosis and autophagy via PI3K/Akt/mTOR pathway in multiple myeloma.9
347649402021Steroid Metabolism in Children and Adolescents With Obesity and Insulin Resistance: Altered SRD5A and 20α/20βHSD Activity.5
348857332021Treatment of Benign Prostatic Hyperplasia by Natural Drugs.24
318705942020Associations of SRD5A1 gene variants and testosterone with dysglycemia: Henan Rural Cohort study.1
327164912020Expression in Escherichia Coli, Purification, and Functional Reconstitution of Human Steroid 5α-Reductases.3
318705942020Associations of SRD5A1 gene variants and testosterone with dysglycemia: Henan Rural Cohort study.1
327164912020Expression in Escherichia Coli, Purification, and Functional Reconstitution of Human Steroid 5α-Reductases.3
311994732019Role of Hepatic Glucocorticoid Receptor in Metabolism in Models of 5αR1 Deficiency in Male Mice.2
311994732019Role of Hepatic Glucocorticoid Receptor in Metabolism in Models of 5αR1 Deficiency in Male Mice.2
2834731520175α-reductase activity in women with polycystic ovary syndrome: a systematic review and meta-analysis.15

Citation

Dessen P

SRD5A1 (steroid 5 alpha-reductase 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43844