Identity
HGNC
LOCATION
12q24.22
LOCUSID
ALIAS
IHPS1,N-NOS,NC-NOS,NOS,bNOS,nNOS
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 4842
MIM: 163731
HGNC: 7872
Ensembl: ENSG00000089250
Variants:
dbSNP: 4842
ClinVar: 4842
TCGA: ENSG00000089250
COSMIC: NOS1
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA128406956 | fluorouracil | Chemical | ClinicalAnnotation | associated | PD | ||
| PA443560 | Breast Neoplasms | Disease | ClinicalAnnotation | associated | PD | ||
| PA445113 | Neutropenia | Disease | ClinicalAnnotation | associated | PD | ||
| PA449165 | cyclophosphamide | Chemical | ClinicalAnnotation | associated | PD | ||
| PA449412 | doxorubicin | Chemical | Pathway | associated | 21048526 | ||
| PA449476 | epirubicin | Chemical | ClinicalAnnotation | associated | PD | ||
| PA449957 | ibuprofen | Chemical | Pathway | associated | 25502615 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36682419 | 2023 | nNOS-induced tyrosine nitration of TRKB impairs BDNF signaling and restrains neuronal plasticity. | 0 |
| 36715280 | 2023 | The Role of Macula Densa Nitric Oxide Synthase 1 Beta Splice Variant in Modulating Tubuloglomerular Feedback. | 2 |
| 38158677 | 2023 | The neuronal nitric oxide synthase expression increases during satellite cell-derived primary myoblasts differentiation. | 0 |
| 36682419 | 2023 | nNOS-induced tyrosine nitration of TRKB impairs BDNF signaling and restrains neuronal plasticity. | 0 |
| 36715280 | 2023 | The Role of Macula Densa Nitric Oxide Synthase 1 Beta Splice Variant in Modulating Tubuloglomerular Feedback. | 2 |
| 38158677 | 2023 | The neuronal nitric oxide synthase expression increases during satellite cell-derived primary myoblasts differentiation. | 0 |
| 35041938 | 2022 | Uncovering associations between mental illness diagnosis, nitric oxide synthase gene variation, and peripheral nitric oxide concentration. | 7 |
| 35821897 | 2022 | The expanding roles of neuronal nitric oxide synthase (NOS1). | 8 |
| 36197968 | 2022 | NOS1 mutations cause hypogonadotropic hypogonadism with sensory and cognitive deficits that can be reversed in infantile mice. | 9 |
| 35041938 | 2022 | Uncovering associations between mental illness diagnosis, nitric oxide synthase gene variation, and peripheral nitric oxide concentration. | 7 |
| 35821897 | 2022 | The expanding roles of neuronal nitric oxide synthase (NOS1). | 8 |
| 36197968 | 2022 | NOS1 mutations cause hypogonadotropic hypogonadism with sensory and cognitive deficits that can be reversed in infantile mice. | 9 |
| 32061134 | 2021 | NOS1AP polymorphisms reduce NOS1 activity and interact with prolonged repolarization in arrhythmogenesis. | 11 |
| 33347982 | 2021 | Association of G84A and C276T polymorphism in neuronal nitric oxide synthase (nNOS) gene with herpes simplex encephalitis in eastern Indian population. | 0 |
| 33434144 | 2021 | Hepatic nNOS impaired hepatic insulin sensitivity through the activation of p38 MAPK. | 3 |
Citation
Dessen P
NOS1 (nitric oxide synthase 1)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/43850/nos1
