NOX1 (NADPH oxidase 1)

2007-02-01  

Identity

HGNC
NOX1
LOCATION
Xq22.1
LOCUSID
27035
ALIAS
GP91-2,MOX1,NOH-1,NOH1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 27035
MIM: 300225
HGNC: 7889
Ensembl: ENSG00000007952

Variants:

dbSNP: 27035
ClinVar: 27035
TCGA: ENSG00000007952
COSMIC: NOX1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000007952ENST00000217885Q9Y5S8
ENSG00000007952ENST00000372960A6NGA6
ENSG00000007952ENST00000372964Q5H9D4
ENSG00000007952ENST00000372966Q9Y5S8
ENSG00000007952ENST00000427768H0Y581

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Leukocyte transendothelial migrationKEGGko04670
Leukocyte transendothelial migrationKEGGhsa04670
NOD-like receptor signaling pathwayKEGGko04621
NOD-like receptor signaling pathwayKEGGhsa04621
PhagosomeKEGGko04145
PhagosomeKEGGhsa04145
Osteoclast differentiationKEGGko04380
Osteoclast differentiationKEGGhsa04380
HIF-1 signaling pathwayKEGGhsa04066
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate NADPH OxidasesREACTOMER-HSA-5668599
AGE-RAGE signaling pathway in diabetic complicationsKEGGko04933
AGE-RAGE signaling pathway in diabetic complicationsKEGGhsa04933
Fluid shear stress and atherosclerosisKEGGko05418
Fluid shear stress and atherosclerosisKEGGhsa05418

References

Pubmed IDYearTitleCitations
385820122024Gut microbiota regulates the ALK5/NOX1 axis by altering glutamine metabolism to inhibit ferroptosis of intrahepatic cholangiocarcinoma cells.0
385820122024Gut microbiota regulates the ALK5/NOX1 axis by altering glutamine metabolism to inhibit ferroptosis of intrahepatic cholangiocarcinoma cells.0
363418442023Serum NOX1 and Raftlin as new potential biomarkers of Major Depressive Disorder: A study in treatment-naive first episode patients.5
366178222023Nrf2 regulates the expression of NOX1 in TNF-α-induced A549 cells.0
367646242023Molecular interplay between NOX1 and autophagy in cadmium-induced prostate carcinogenesis.4
372248112023PROX1 induction by autolysosomal activity stabilizes persister-like state of colon cancer via feedback repression of the NOX1-mTORC1 pathway.1
363418442023Serum NOX1 and Raftlin as new potential biomarkers of Major Depressive Disorder: A study in treatment-naive first episode patients.5
366178222023Nrf2 regulates the expression of NOX1 in TNF-α-induced A549 cells.0
367646242023Molecular interplay between NOX1 and autophagy in cadmium-induced prostate carcinogenesis.4
372248112023PROX1 induction by autolysosomal activity stabilizes persister-like state of colon cancer via feedback repression of the NOX1-mTORC1 pathway.1
359600912022Increased NOX1 and DUOX2 expression in the colonic mucosa of patients with chronic functional constipation.4
359600912022Increased NOX1 and DUOX2 expression in the colonic mucosa of patients with chronic functional constipation.4
334853642021NOX1 inhibition attenuates the development of a pro-tumorigenic environment in experimental hepatocellular carcinoma.10
337574672021Nuclear factor-kappaB regulates the transcription of NADPH oxidase 1 in human alveolar epithelial cells.8
334853642021NOX1 inhibition attenuates the development of a pro-tumorigenic environment in experimental hepatocellular carcinoma.10

Citation

Dessen P

NOX1 (NADPH oxidase 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43856/js/img/meetings/