SUV39H1 (suppressor of variegation 3-9 homolog 1)

2007-02-01  

Identity

HGNC
LOCATION
Xp11.23
LOCUSID
ALIAS
H3-K9-HMTase 1,KMT1A,MG44,SUV39H
FUSION GENES

Other Information

Locus ID:

NCBI: 6839
MIM: 300254
HGNC: 11479
Ensembl: ENSG00000101945

Variants:

dbSNP: 6839
ClinVar: 6839
TCGA: ENSG00000101945
COSMIC: SUV39H1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000101945ENST00000337852O43463
ENSG00000101945ENST00000376687O43463

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
Lysine degradationKEGGko00310
Lysine degradationKEGGhsa00310
Gene ExpressionREACTOMER-HSA-74160
Epigenetic regulation of gene expressionREACTOMER-HSA-212165
Negative epigenetic regulation of rRNA expressionREACTOMER-HSA-5250941
SIRT1 negatively regulates rRNA ExpressionREACTOMER-HSA-427359
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
PKMTs methylate histone lysinesREACTOMER-HSA-3214841

References

Pubmed IDYearTitleCitations
381768982024Histone methyltransferase Suv39h1 regulates hepatic stellate cell activation and is targetable in liver fibrosis.1
381774112024The Wnt-pathway corepressor TLE3 interacts with the histone methyltransferase KMT1A to inhibit differentiation in Rhabdomyosarcoma.0
381768982024Histone methyltransferase Suv39h1 regulates hepatic stellate cell activation and is targetable in liver fibrosis.1
381774112024The Wnt-pathway corepressor TLE3 interacts with the histone methyltransferase KMT1A to inhibit differentiation in Rhabdomyosarcoma.0
370292392023SUV39H1 is a prognosis and immune microenvironment-related biomarker in diffuse large B-cell lymphoma.0
380173862023SUV39H1 is a novel biomarker targeting oxidative phosphorylation in hepatitis B virus-associated hepatocellular carcinoma.2
370292392023SUV39H1 is a prognosis and immune microenvironment-related biomarker in diffuse large B-cell lymphoma.0
380173862023SUV39H1 is a novel biomarker targeting oxidative phosphorylation in hepatitis B virus-associated hepatocellular carcinoma.2
357684322022CD8+T cell responsiveness to anti-PD-1 is epigenetically regulated by Suv39h1 in melanomas.13
361491942022Differences in SUV39H1 and androgen receptor distribution in adenomyomatous hyperplasia and prostatic adenocarcinoma.0
365363722022Decreased SUV39H1 at the promoter region leads to increased CREMα and accelerates autoimmune response in CD4(+) T cells from patients with systemic lupus erythematosus.0
357684322022CD8+T cell responsiveness to anti-PD-1 is epigenetically regulated by Suv39h1 in melanomas.13
361491942022Differences in SUV39H1 and androgen receptor distribution in adenomyomatous hyperplasia and prostatic adenocarcinoma.0
365363722022Decreased SUV39H1 at the promoter region leads to increased CREMα and accelerates autoimmune response in CD4(+) T cells from patients with systemic lupus erythematosus.0
331969692021MiR-520a-3p inhibits malignant progression of epithelial ovarian cancer by targeting SUV39H1 expression.10

Citation

Dessen P

SUV39H1 (suppressor of variegation 3-9 homolog 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43860/suv39h1