Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 9002
MIM: 602779
HGNC: 3540
Ensembl: ENSG00000127533
Variants:
dbSNP: 9002
ClinVar: 9002
TCGA: ENSG00000127533
COSMIC: F2RL3
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000127533 | ENST00000248076 | Q96RI0 |
| ENSG00000127533 | ENST00000599210 | M0R0Y0 |
Expression (GTEx)
Pathways
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA157 | F2 | Gene | Pathway | associated | 20938371 | ||
| PA174 | GNAQ | Gene | Pathway | associated | 20938371 | ||
| PA176 | GNB3 | Gene | Pathway | associated | 20938371 | ||
| PA28764 | GNA11 | Gene | Pathway | associated | 20938371 | ||
| PA28765 | GNA12 | Gene | Pathway | associated | 20938371 | ||
| PA28766 | GNA13 | Gene | Pathway | associated | 20938371 | ||
| PA28768 | GNA15 | Gene | Pathway | associated | 20938371 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38051301 | 2024 | The Influence of Smoking and Occupational Risk Factors on DNA Methylation in the AHRR and F2RL3 Genes. | 0 |
| 38051301 | 2024 | The Influence of Smoking and Occupational Risk Factors on DNA Methylation in the AHRR and F2RL3 Genes. | 0 |
| 37233402 | 2023 | Strong correlation between F2RL3 in the blood and osteoarthritis based on a retrospective cohort study. | 0 |
| 37471144 | 2023 | The predominant PAR4 variant in individuals of African ancestry worsens murine and human stroke outcomes. | 5 |
| 37233402 | 2023 | Strong correlation between F2RL3 in the blood and osteoarthritis based on a retrospective cohort study. | 0 |
| 37471144 | 2023 | The predominant PAR4 variant in individuals of African ancestry worsens murine and human stroke outcomes. | 5 |
| 34852379 | 2022 | The PAR4 Platelet Thrombin Receptor Variant rs773902 does not Impact the Incidence of Thrombotic or Bleeding Events in a Healthy Older Population. | 1 |
| 35012325 | 2022 | Epigenetic Regulation of F2RL3 Associates With Myocardial Infarction and Platelet Function. | 4 |
| 35152546 | 2022 | Human and mouse PAR4 are functionally distinct receptors: Studies in novel humanized mice. | 3 |
| 35343875 | 2022 | An optimized agonist peptide of protease-activated receptor 4 and its use in a validated platelet-aggregation assay. | 1 |
| 34852379 | 2022 | The PAR4 Platelet Thrombin Receptor Variant rs773902 does not Impact the Incidence of Thrombotic or Bleeding Events in a Healthy Older Population. | 1 |
| 35012325 | 2022 | Epigenetic Regulation of F2RL3 Associates With Myocardial Infarction and Platelet Function. | 4 |
| 35152546 | 2022 | Human and mouse PAR4 are functionally distinct receptors: Studies in novel humanized mice. | 3 |
| 35343875 | 2022 | An optimized agonist peptide of protease-activated receptor 4 and its use in a validated platelet-aggregation assay. | 1 |
| 33812377 | 2021 | PAR-4/Ca(2+)-calpain pathway activation stimulates platelet-derived microparticles in hyperglycemic type 2 diabetes. | 6 |
Citation
Dessen P
F2RL3 (F2R like thrombin or trypsin receptor 3)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/43864/f2rl3
