Identity
HGNC
LOCATION
6p21.32
LOCUSID
ALIAS
CELIAC1,HLA-DQB,IDDM1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 3119
MIM: 604305
HGNC: 4944
Ensembl: ENSG00000179344
Variants:
dbSNP: 3119
ClinVar: 3119
TCGA: ENSG00000179344
COSMIC: HLA-DQB1
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA131285571 | aspirin-induced asthma | Disease | VariantAnnotation | ambiguous | PD | 15007363, 26366802 | |
| PA164712708 | Drugs For Treatment Of Tuberculosis | Chemical | VariantAnnotation | associated | PD | 12359646, 25250564 | |
| PA164712830 | Influenza vaccines | Chemical | ClinicalAnnotation, VariantAnnotation | ambiguous | PD | 11756990, 21102981, 22249484, 23486871, 25264897 | |
| PA164742987 | clavulanate | Chemical | ClinicalAnnotation, VariantAnnotation | associated | PD | 10535882, 30664875 | |
| PA164769031 | lumiracoxib | Chemical | VariantAnnotation | associated | PD | 20639878 | |
| PA164781042 | flucloxacillin | Chemical | VariantAnnotation | associated | PD | 30664875 | |
| PA164925725 | Toxic liver disease | Disease | VariantAnnotation | ambiguous | PD | 12359646, 17339877, 20639878 | |
| PA166119041 | drug-induced liver injury | Disease | ClinicalAnnotation, VariantAnnotation | ambiguous | PD | 25250564, 26959717, 27206238, 30664875 | |
| PA166120927 | drug reaction with eosinophilia and systemic symptoms | Disease | VariantAnnotation | associated | PD | ||
| PA166120929 | severe cutaneous adverse reactions | Disease | ClinicalAnnotation, VariantAnnotation | associated | PD | 19668019, 21545408, 24399721 | |
| PA166123368 | schizoaffective disorder | Disease | VariantAnnotation | not associated | PD | 2222133 | |
| PA166123566 | bucillamine | Chemical | VariantAnnotation | associated | PD | ||
| PA166151827 | adverse events | Disease | VariantAnnotation | not associated | PD | 30020991 | |
| PA166152829 | flupirtine | Chemical | ClinicalAnnotation, VariantAnnotation | associated | PD | 26959717 | |
| PA443297 | Agranulocytosis | Disease | VariantAnnotation | ambiguous | PD | 11146763, 11266078, 2222133, 27168101 | |
| PA443434 | Arthritis, Rheumatoid | Disease | VariantAnnotation | associated | PD | ||
| PA443895 | Diabetic Retinopathy | Disease | MultilinkAnnotation | associated | 26807609 | ||
| PA443936 | Drug Hypersensitivity | Disease | ClinicalAnnotation, VariantAnnotation | ambiguous | PD | 21545408 | |
| PA443937 | Drug Toxicity | Disease | ClinicalAnnotation | associated | PD | ||
| PA444059 | Epidermal Necrolysis, Toxic | Disease | ClinicalAnnotation, VariantAnnotation | ambiguous | PD | 21545408 | |
| PA444065 | Epilepsy | Disease | VariantAnnotation | ambiguous | PD | 24399721, 30020991 | |
| PA444435 | Hepatitis | Disease | VariantAnnotation | associated | PD | 10535882 | |
| PA444552 | Hypertension | Disease | Literature, MultilinkAnnotation | associated | 24560520 | ||
| PA444614 | Infection | Disease | VariantAnnotation | associated | PD | 10535882 | |
| PA445042 | Narcolepsy | Disease | ClinicalAnnotation, VariantAnnotation | ambiguous | PD | 21102981, 22249484, 23486871, 25264897 | |
| PA445113 | Neutropenia | Disease | VariantAnnotation | not associated | PD | 27168101 | |
| PA445431 | Proteinuria | Disease | VariantAnnotation | associated | PD | ||
| PA445738 | Stevens-Johnson Syndrome | Disease | ClinicalAnnotation, VariantAnnotation | ambiguous | PD | 21545408 | |
| PA445941 | Tuberculosis | Disease | VariantAnnotation | ambiguous | PD | 12359646, 25250564 | |
| PA445999 | Urticaria | Disease | VariantAnnotation | associated | PD | 15784113, 19392989 | |
| PA447216 | Schizophrenia | Disease | VariantAnnotation | ambiguous | PD | 11146763, 11266078, 2222133 | |
| PA447230 | HIV | Disease | VariantAnnotation | associated | PD | ||
| PA448015 | acetaminophen | Chemical | ClinicalAnnotation, VariantAnnotation | associated | PD | 21545408 | |
| PA448320 | allopurinol | Chemical | ClinicalAnnotation, VariantAnnotation | ambiguous | PD | 21545408 | |
| PA448406 | amoxicillin | Chemical | ClinicalAnnotation, VariantAnnotation | associated | PD | 10535882, 30664875 | |
| PA448497 | aspirin | Chemical | VariantAnnotation | associated | PD | 15784113, 19392989, 26366802 | |
| PA448785 | carbamazepine | Chemical | VariantAnnotation | associated | PD | 24399721 | |
| PA449061 | clozapine | Chemical | VariantAnnotation | ambiguous | PD | 11146763, 11266078, 2222133, 27168101 | |
| PA450112 | isoniazid | Chemical | VariantAnnotation | not associated | PD | ||
| PA450164 | lamotrigine | Chemical | VariantAnnotation | associated | PD | 19668019 | |
| PA450206 | levetiracetam | Chemical | VariantAnnotation | not associated | PD | 30020991 | |
| PA450616 | nevirapine | Chemical | ClinicalAnnotation, VariantAnnotation | associated | PD | ||
| PA451182 | pyrazinamide | Chemical | VariantAnnotation | not associated | PD | ||
| PA451250 | rifampin | Chemical | VariantAnnotation | not associated | PD | ||
| PA451686 | ticlopidine | Chemical | VariantAnnotation | associated | PD | 17339877 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37406822 | 2024 | The protective association of HLA-B∗52:01, HLA-C∗12:02, and DQB1∗06:01 alleles with severe acute hepatitis of unknown origin in Japanese children. | 0 |
| 37652095 | 2024 | A Celiac Gene HLA-DQB1∗02:01 Is Associated with Linear IgA Bullous Dermatosis in the Chinese Population. | 0 |
| 37697931 | 2024 | The protective association of HLA-C*12:02 and HLA-DQB1*06:01 with severe acute hepatitis of unknown origin in the Japanese population. | 0 |
| 37884160 | 2024 | HLA-C*07:01 and HLA-DQB1*02:01 protect against white matter hyperintensities and deterioration of cognitive function: A population-based cohort study. | 1 |
| 38579189 | 2024 | Genome-Wide Association Study Identifies IFIH1 and HLA-DQB1*05:02 Loci Associated With Anti-NMDAR Encephalitis. | 1 |
| 38799118 | 2024 | HLA-DQB1 Allele Polymorphism Associated with Oral Submucous Fibrosis in Hunan, China. | 0 |
| 37406822 | 2024 | The protective association of HLA-B∗52:01, HLA-C∗12:02, and DQB1∗06:01 alleles with severe acute hepatitis of unknown origin in Japanese children. | 0 |
| 37652095 | 2024 | A Celiac Gene HLA-DQB1∗02:01 Is Associated with Linear IgA Bullous Dermatosis in the Chinese Population. | 0 |
| 37697931 | 2024 | The protective association of HLA-C*12:02 and HLA-DQB1*06:01 with severe acute hepatitis of unknown origin in the Japanese population. | 0 |
| 37884160 | 2024 | HLA-C*07:01 and HLA-DQB1*02:01 protect against white matter hyperintensities and deterioration of cognitive function: A population-based cohort study. | 1 |
| 38579189 | 2024 | Genome-Wide Association Study Identifies IFIH1 and HLA-DQB1*05:02 Loci Associated With Anti-NMDAR Encephalitis. | 1 |
| 38799118 | 2024 | HLA-DQB1 Allele Polymorphism Associated with Oral Submucous Fibrosis in Hunan, China. | 0 |
| 35523683 | 2023 | Role of HLA-DQB1 alleles in the risk, signs and symptoms, and severity of celiac disease in a Venezuelan population. | 0 |
| 36468571 | 2023 | DQA1*0102 DQB1*0602 haplotype distinguishes coeliac disease and its complications from gluten unrelated enteropathies. | 0 |
| 36592642 | 2023 | Association of HLADQ-B1 polymorphisms in three generations of chronic hepatitis B patients. | 3 |
Citation
Dessen P
HLA-DQB1 (major histocompatibility complex, class II, DQ beta 1)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/43867/hla-dqb1
