FYCO1 (FYVE and coiled-coil domain autophagy adaptor 1)

2007-02-01 Affiliation

Identity

HGNC

FYCO1

LOCATION

3p21.31

LOCUSID

79443

ALIAS

CATC2,CTRCT18,RUFY3,ZFYVE7

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 79443
MIM: 607182
HGNC: 14673
Ensembl: ENSG00000163820

Variants:

dbSNP: 79443
ClinVar: 79443
TCGA: ENSG00000163820
COSMIC: FYCO1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000163820	ENST00000296137	Q9BQS8
ENSG00000163820	ENST00000433878	H7BZ74
ENSG00000163820	ENST00000438446	C9J2W6
ENSG00000163820	ENST00000535325	Q9BQS8

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
35638468	2022	Targeted gene sequencing of FYCO1 identified a novel mutation in a Pakistani family for autosomal recessive congenital cataract.	2
36061348	2022	A Novel Mutation in the FYCO1 Gene Causing Congenital Cataract: Case Study of a Chinese Family.	0
36342046	2022	FYCO1 regulates migration, invasion, and invadopodia formation in HeLa cells through CDC42/N-WASP/Arp2/3 signaling pathway.	3
35638468	2022	Targeted gene sequencing of FYCO1 identified a novel mutation in a Pakistani family for autosomal recessive congenital cataract.	2
36061348	2022	A Novel Mutation in the FYCO1 Gene Causing Congenital Cataract: Case Study of a Chinese Family.	0
36342046	2022	FYCO1 regulates migration, invasion, and invadopodia formation in HeLa cells through CDC42/N-WASP/Arp2/3 signaling pathway.	3
33649539	2021	Lung expression of genes putatively involved in SARS-CoV-2 infection is modulated in cis by germline variants.	10
33767456	2021	Autosomal recessive cataract (CTRCT18) in the Yakut population isolate of Eastern Siberia: a novel founder variant in the FYCO1 gene.	7
33859171	2021	Nlp promotes autophagy through facilitating the interaction of Rab7 and FYCO1.	10
34282983	2021	Identification of a novel nonsense variant in FYCO1 gene associated with infantile cataract and cortical atrophy.	3
33649539	2021	Lung expression of genes putatively involved in SARS-CoV-2 infection is modulated in cis by germline variants.	10
33767456	2021	Autosomal recessive cataract (CTRCT18) in the Yakut population isolate of Eastern Siberia: a novel founder variant in the FYCO1 gene.	7
33859171	2021	Nlp promotes autophagy through facilitating the interaction of Rab7 and FYCO1.	10
34282983	2021	Identification of a novel nonsense variant in FYCO1 gene associated with infantile cataract and cortical atrophy.	3
32744243	2020	Crystal structure of the FYCO1 RUN domain suggests possible interfaces with small GTPases.	3

Citation

Dessen P

FYCO1 (FYVE and coiled-coil domain autophagy adaptor 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43868/haematological-explorer/js/lib/img/logo-atlas-4.svg