IL4R (interleukin 4 receptor)

2007-02-01  

Identity

HGNC
IL4R
LOCATION
16p12.1
LOCUSID
3566
ALIAS
CD124,IL-4RA,IL4RA
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3566
MIM: 147781
HGNC: 6015
Ensembl: ENSG00000077238

Variants:

dbSNP: 3566
ClinVar: 3566
TCGA: ENSG00000077238
COSMIC: IL4R

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000077238ENST00000170630P24394
ENSG00000077238ENST00000395762P24394
ENSG00000077238ENST00000543915P24394
ENSG00000077238ENST00000561742A0A0G2JLA1
ENSG00000077238ENST00000562142H3BTD9
ENSG00000077238ENST00000562968H3BSE7
ENSG00000077238ENST00000563002J9JII2
ENSG00000077238ENST00000563926Q5FC08
ENSG00000077238ENST00000565179I3L4W9
ENSG00000077238ENST00000565352I3L4H7
ENSG00000077238ENST00000566117J9JII2
ENSG00000077238ENST00000566318H3BRH7
ENSG00000077238ENST00000568746Q5FC08
ENSG00000077238ENST00000628578Q5FC08

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Jak-STAT signaling pathwayKEGGko04630
Hematopoietic cell lineageKEGGko04640
Cytokine-cytokine receptor interactionKEGGhsa04060
Jak-STAT signaling pathwayKEGGhsa04630
Hematopoietic cell lineageKEGGhsa04640
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Inflammatory bowel disease (IBD)KEGGhsa05321
Inflammatory bowel disease (IBD)KEGGko05321
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Th1 and Th2 cell differentiationKEGGko04658
Th1 and Th2 cell differentiationKEGGhsa04658
Th17 cell differentiationKEGGko04659
Th17 cell differentiationKEGGhsa04659
Interleukin-4 and 13 signalingREACTOMER-HSA-6785807

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA164712789Hepatitis vaccinesChemicalClinicalAnnotationassociatedPD21111021
PA165983754pitrakinraChemicalClinicalAnnotationassociatedPD
PA443450AsthmaDiseaseClinicalAnnotationassociatedPD

References

Pubmed IDYearTitleCitations
379334662024Th2 cytokine signaling through IL-4Rα increases eotaxin-3 secretion and tension in human esophageal smooth muscle.0
384268662024Global IL4Rα blockade exacerbates heart failure after an ischemic event in mice and humans.0
387318672024Type II Interleukin-4 Receptor Activation in Basal Breast Cancer Cells Promotes Tumor Progression via Metabolic and Epigenetic Modulation.0
379334662024Th2 cytokine signaling through IL-4Rα increases eotaxin-3 secretion and tension in human esophageal smooth muscle.0
384268662024Global IL4Rα blockade exacerbates heart failure after an ischemic event in mice and humans.0
387318672024Type II Interleukin-4 Receptor Activation in Basal Breast Cancer Cells Promotes Tumor Progression via Metabolic and Epigenetic Modulation.0
360700832023Epithelial cell-expressed type II IL-4 receptor mediates eosinophilic esophagitis.9
364450142023IgG memory B cells expressing IL4R and FCER2 are associated with atopic diseases.5
371173312023Prognosis value and positive association of Rab1A/IL4Rα aberrant expression in gastric cancer.0
375515482023Association of IL4RA polymorphism in predicting susceptibility toward chronic obstructive pulmonary disease.0
360700832023Epithelial cell-expressed type II IL-4 receptor mediates eosinophilic esophagitis.9
364450142023IgG memory B cells expressing IL4R and FCER2 are associated with atopic diseases.5
371173312023Prognosis value and positive association of Rab1A/IL4Rα aberrant expression in gastric cancer.0
375515482023Association of IL4RA polymorphism in predicting susceptibility toward chronic obstructive pulmonary disease.0
355890102022Atopic Dermatitis Mediates the Association Between an IL4RA Variant and Food Allergy in School-Aged Children.3

Citation

Dessen P

IL4R (interleukin 4 receptor)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43873/favicon/js/lib/zoomerang.js