SF3B4 (splicing factor 3b subunit 4)

2007-02-01  

Identity

HGNC
LOCATION
1q21.2
LOCUSID
ALIAS
AFD1,Hsh49,SAP49,SF3b49

Other Information

Locus ID:

NCBI: 10262
MIM: 605593
HGNC: 10771
Ensembl: ENSG00000143368

Variants:

dbSNP: 10262
ClinVar: 10262
TCGA: ENSG00000143368
COSMIC: SF3B4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000143368ENST00000271628Q15427
ENSG00000143368ENST00000457312Q5SZ64

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
SpliceosomeKEGGko03040
SpliceosomeKEGGhsa03040
Spliceosome, U2-snRNPKEGGhsa_M00352
Spliceosome, U2-snRNPKEGGM00352
Gene ExpressionREACTOMER-HSA-74160
Processing of Capped Intron-Containing Pre-mRNAREACTOMER-HSA-72203
mRNA SplicingREACTOMER-HSA-72172
mRNA Splicing - Major PathwayREACTOMER-HSA-72163
mRNA Splicing - Minor PathwayREACTOMER-HSA-72165

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
383172002024SETDB1 promotes progression through upregulation of SF3B4 expression and regulates the immunity in ovarian cancer.0
384627402024METTL3-mediated the m6A modification of SF3B4 facilitates the development of non-small cell lung cancer by enhancing LSM4 expression.1
383172002024SETDB1 promotes progression through upregulation of SF3B4 expression and regulates the immunity in ovarian cancer.0
384627402024METTL3-mediated the m6A modification of SF3B4 facilitates the development of non-small cell lung cancer by enhancing LSM4 expression.1
366396792023SF3B4 promotes Twist1 expression and clear cell renal cell carcinoma progression by facilitating the export of KLF 16 mRNA from the nucleus to the cytoplasm.2
366396792023SF3B4 promotes Twist1 expression and clear cell renal cell carcinoma progression by facilitating the export of KLF 16 mRNA from the nucleus to the cytoplasm.2
350309772022Enabled homolog (ENAH) regulated by RNA binding protein splicing factor 3b subunit 4 (SF3B4) exacerbates the proliferation, invasion and migration of hepatocellular carcinoma cells via Notch signaling pathway.5
352104122022SF3B4 promotes ovarian cancer progression by regulating alternative splicing of RAD52.8
359968262022SF3B4 Depletion Retards the Growth of A549 Non-Small Cell Lung Cancer Cells via UBE4B-Mediated Regulation of p53/p21 and p27 Expression.4
350309772022Enabled homolog (ENAH) regulated by RNA binding protein splicing factor 3b subunit 4 (SF3B4) exacerbates the proliferation, invasion and migration of hepatocellular carcinoma cells via Notch signaling pathway.5
352104122022SF3B4 promotes ovarian cancer progression by regulating alternative splicing of RAD52.8
359968262022SF3B4 Depletion Retards the Growth of A549 Non-Small Cell Lung Cancer Cells via UBE4B-Mediated Regulation of p53/p21 and p27 Expression.4
335594012021Nager syndrome in patient lacking acrofacial dysostosis: Expanding the phenotypic spectrum of SF3B4-related disease.0
352209982021The Role of Splicing Factor SF3B4 in Congenital Diseases and Tumors.4
335594012021Nager syndrome in patient lacking acrofacial dysostosis: Expanding the phenotypic spectrum of SF3B4-related disease.0

Citation

Dessen P

SF3B4 (splicing factor 3b subunit 4)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43881/sf3b4