CCT6A (chaperonin containing TCP1 subunit 6A)

2007-02-01  

Identity

HGNC
LOCATION
7p11.2
LOCUSID
ALIAS
CCT-zeta,CCT-zeta-1,CCT6,Cctz,HTR3,MoDP-2,TCP-1-zeta,TCP20,TCPZ,TTCP20

Other Information

Locus ID:

NCBI: 908
MIM: 104613
HGNC: 1620
Ensembl: ENSG00000146731

Variants:

dbSNP: 908
ClinVar: 908
TCGA: ENSG00000146731
COSMIC: CCT6A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000146731ENST00000275603P40227
ENSG00000146731ENST00000275603A0A024RDL1
ENSG00000146731ENST00000335503P40227

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Protein foldingREACTOMER-HSA-391251
Chaperonin-mediated protein foldingREACTOMER-HSA-390466
Cooperation of Prefoldin and TriC/CCT in actin and tubulin foldingREACTOMER-HSA-389958
Prefoldin mediated transfer of substrate to CCT/TriCREACTOMER-HSA-389957
Formation of tubulin folding intermediates by CCT/TriCREACTOMER-HSA-389960
Folding of actin by CCT/TriCREACTOMER-HSA-390450
Association of TriC/CCT with target proteins during biosynthesisREACTOMER-HSA-390471
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta foldingREACTOMER-HSA-6814122

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
380848682024Chaperonin containing TCP1 subunit 6A may activate Notch and Wnt pathways to facilitate the malignant behaviors and cancer stemness in oral squamous cell carcinoma.0
380848682024Chaperonin containing TCP1 subunit 6A may activate Notch and Wnt pathways to facilitate the malignant behaviors and cancer stemness in oral squamous cell carcinoma.0
370178542023CCT6A promotes esophageal squamous cell carcinoma cell proliferation, invasion and epithelial-mesenchymal transition by activating TGF-β/Smad/c-Myc pathway.2
370178542023CCT6A promotes esophageal squamous cell carcinoma cell proliferation, invasion and epithelial-mesenchymal transition by activating TGF-β/Smad/c-Myc pathway.2
345001192022CCT6A expression in hepatocellular carcinoma and its correlation with clinical characteristics, liver function indexes, tumor markers and prognosis.6
353468912022Chaperonin-containing tailless complex polypeptide 1 subunit 6A links with aggravating tumor features and disease-free survival in surgical gastric cancer patients: A long-term follow-up study.3
365841472022CCT6A knockdown suppresses osteosarcoma cell growth and Akt pathway activation in vitro.2
345001192022CCT6A expression in hepatocellular carcinoma and its correlation with clinical characteristics, liver function indexes, tumor markers and prognosis.6
353468912022Chaperonin-containing tailless complex polypeptide 1 subunit 6A links with aggravating tumor features and disease-free survival in surgical gastric cancer patients: A long-term follow-up study.3
365841472022CCT6A knockdown suppresses osteosarcoma cell growth and Akt pathway activation in vitro.2
335302652021CCT6A, a novel prognostic biomarker for Ewing sarcoma.14
341969922021CCT6A may act as a potential biomarker reflecting tumor size, lymphatic metastasis, FIGO stage, and prognosis in cervical cancer patients.9
343129252021Chaperonin-containing tailless complex polypeptide 1 subunit 6A correlates with increased World Health Organization grade, less isocitrate dehydrogenase mutation, and deteriorative survival of astrocytoma patients.4
344341882021Dynamic Network Biomarker of Pre-Exhausted CD8(+) T Cells Contributed to T Cell Exhaustion in Colorectal Cancer.13
335302652021CCT6A, a novel prognostic biomarker for Ewing sarcoma.14

Citation

Dessen P

CCT6A (chaperonin containing TCP1 subunit 6A)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43884/cct6a