CLCA1 (chloride channel accessory 1)

2007-02-01  

Identity

HGNC
LOCATION
1p22.3
LOCUSID
ALIAS
CACC,CACC1,CLCRG1,CaCC-1,GOB5,hCLCA1,hCaCC-1

Other Information

Locus ID:

NCBI: 1179
MIM: 603906
HGNC: 2015
Ensembl: ENSG00000016490

Variants:

dbSNP: 1179
ClinVar: 1179
TCGA: ENSG00000016490
COSMIC: CLCA1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000016490ENST00000234701A8K7I4
ENSG00000016490ENST00000394711A8K7I4

Expression (GTEx)

0
50
100
150
200
250
300
350

Pathways

PathwaySourceExternal ID
Pancreatic secretionKEGGko04972
Pancreatic secretionKEGGhsa04972
Renin secretionKEGGhsa04924
Renin secretionKEGGko04924
Transmembrane transport of small moleculesREACTOMER-HSA-382551
Ion channel transportREACTOMER-HSA-983712
Stimuli-sensing channelsREACTOMER-HSA-2672351

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
385931252024Rab7-dependent regulation of goblet cell protein CLCA1 modulates gastrointestinal homeostasis.0
385974202024CLCA1 exacerbates lung inflammation via p38 MAPK pathway in acute respiratory distress syndrome.0
385931252024Rab7-dependent regulation of goblet cell protein CLCA1 modulates gastrointestinal homeostasis.0
385974202024CLCA1 exacerbates lung inflammation via p38 MAPK pathway in acute respiratory distress syndrome.0
319957322020Structural and Biophysical Analysis of the CLCA1 VWA Domain Suggests Mode of TMEM16A Engagement.7
319957322020Structural and Biophysical Analysis of the CLCA1 VWA Domain Suggests Mode of TMEM16A Engagement.7
315705262019Calcium-activated chloride channel regulator 1 (CLCA1) forms non-covalent oligomers in colonic mucus and has mucin 2-processing properties.20
315705262019Calcium-activated chloride channel regulator 1 (CLCA1) forms non-covalent oligomers in colonic mucus and has mucin 2-processing properties.20
298858642018Calcium-activated Chloride Channel Regulator 1 (CLCA1) Controls Mucus Expansion in Colon by Proteolytic Activity.45
298858642018Calcium-activated Chloride Channel Regulator 1 (CLCA1) Controls Mucus Expansion in Colon by Proteolytic Activity.45
284207322017Modulation of TMEM16A channel activity by the von Willebrand factor type A (VWA) domain of the calcium-activated chloride channel regulator 1 (CLCA1).23
289742312017CLCA1 suppresses colorectal cancer aggressiveness via inhibition of the Wnt/beta-catenin signaling pathway.35
284207322017Modulation of TMEM16A channel activity by the von Willebrand factor type A (VWA) domain of the calcium-activated chloride channel regulator 1 (CLCA1).23
289742312017CLCA1 suppresses colorectal cancer aggressiveness via inhibition of the Wnt/beta-catenin signaling pathway.35
256039122015Low expression of chloride channel accessory 1 predicts a poor prognosis in colorectal cancer.27

Citation

Dessen P

CLCA1 (chloride channel accessory 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43899/clca1