CTLA4 (cytotoxic T-lymphocyte associated protein 4)

2007-02-01  

Identity

HGNC
CTLA4
LOCATION
2q33.2
LOCUSID
1493
ALIAS
ALPS5,CD,CD152,CELIAC3,CTLA-4,GRD4,GSE,IDDM12
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1493
MIM: 123890
HGNC: 2505
Ensembl: ENSG00000163599

Variants:

dbSNP: 1493
ClinVar: 1493
TCGA: ENSG00000163599
COSMIC: CTLA4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000163599ENST00000295854P16410
ENSG00000163599ENST00000472206P16410
ENSG00000163599ENST00000487393P16410
ENSG00000163599ENST00000648405P16410

Expression (GTEx)

0
1
2
3
4
5
6
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cell adhesion molecules (CAMs)KEGGko04514
T cell receptor signaling pathwayKEGGko04660
Autoimmune thyroid diseaseKEGGko05320
Cell adhesion molecules (CAMs)KEGGhsa04514
T cell receptor signaling pathwayKEGGhsa04660
Autoimmune thyroid diseaseKEGGhsa05320
Rheumatoid arthritisKEGGko05323
Rheumatoid arthritisKEGGhsa05323
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Costimulation by the CD28 familyREACTOMER-HSA-388841
CTLA4 inhibitory signalingREACTOMER-HSA-389513

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA10252bortezomibChemicalClinicalAnnotationassociatedPD21228734
PA164712462Antiinflammatory agents, non-steroidsChemicalClinicalAnnotationassociatedPD28750137
PA164713366Tumor necrosis factor alpha (TNF-alpha) inhibitorsChemicalClinicalAnnotationassociatedPD26194362
PA165817016Kidney TransplantationDiseaseClinicalAnnotationassociatedPKPD18021981
PA445451PsoriasisDiseaseClinicalAnnotationassociatedPD26194362
PA449167cyclosporineChemicalClinicalAnnotationassociatedPD18021981
PA449247dexamethasoneChemicalClinicalAnnotationassociatedPD21228734
PA450354melphalanChemicalClinicalAnnotationassociatedPD21228734
PA451100prednisoneChemicalClinicalAnnotationassociatedPD21228734
PA451578tacrolimusChemicalClinicalAnnotationassociatedPK

References

Pubmed IDYearTitleCitations
369182732024Implications of LAG3 and CTLA4 immune checkpoints beyond PD-1/PD-L1 as a potential target in determining the prognosis of uveal melanoma patients.3
376799672024Association between CTLA4 + 49A/G polymorphism and risk of hepatocellular carcinoma: a systematic review and meta-analysis.0
380422202024Dual silencing of tumor-intrinsic VISTA and CTLA-4 stimulates T-cell mediated immune responses and inhibits MCF7 breast cancer development.1
381809942024Detection of CTLA-4 level and humeral immune response after the second dose of COVID-19 vaccine in certain Iraqi provinces participants.0
384174422024Lactate modulates RNA splicing to promote CTLA-4 expression in tumor-infiltrating regulatory T cells.3
385205762024CTLA-4 expression and polymorphisms in Schizophrenia; a systematic review of literature.0
385360232024TIM3 and CTLA4 immune checkpoint polymorphisms are associated with acute myeloid leukemia in Saudi Arabia.0
387230112024Association of tuberculosis risk with genetic polymorphisms of the immune checkpoint genes PDCD1, CTLA-4, and TIM3.0
388522892024Targeting the dynamic transcriptional landscape of Treg subpopulations in pancreatic ductal adenocarcinoma: Insights from single-cell RNA sequencing analysis with a focus on CTLA4 and TIGIT.0
388670482024CTLA-4-expressing ILC3s restrain interleukin-23-mediated inflammation.0
389559182024CTLA-4 silencing could promote anti-tumor effects in hepatocellular.0
369182732024Implications of LAG3 and CTLA4 immune checkpoints beyond PD-1/PD-L1 as a potential target in determining the prognosis of uveal melanoma patients.3
376799672024Association between CTLA4 + 49A/G polymorphism and risk of hepatocellular carcinoma: a systematic review and meta-analysis.0
380422202024Dual silencing of tumor-intrinsic VISTA and CTLA-4 stimulates T-cell mediated immune responses and inhibits MCF7 breast cancer development.1
381809942024Detection of CTLA-4 level and humeral immune response after the second dose of COVID-19 vaccine in certain Iraqi provinces participants.0

Citation

Dessen P

CTLA4 (cytotoxic T-lymphocyte associated protein 4)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43902