Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 2224
MIM: 134629
HGNC: 3631
Ensembl: ENSG00000160752
Variants:
dbSNP: 2224
ClinVar: 2224
TCGA: ENSG00000160752
COSMIC: FDPS
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA10235 | zoledronate | Chemical | ClinicalAnnotation | associated | PD | 21196316 | |
| PA164712563 | Bisphosphonates | Chemical | ClinicalAnnotation | associated | PD | 18687167, 21151198, 24311107 | |
| PA443797 | Coronary Disease | Disease | ClinicalAnnotation | associated | PD | 21151198, 24311107 | |
| PA445062 | Neoplasms | Disease | ClinicalAnnotation | associated | PD | 21196316 | |
| PA445187 | Osteonecrosis | Disease | ClinicalAnnotation | associated | PD | 21196316 | |
| PA445190 | Osteoporosis | Disease | ClinicalAnnotation | associated | PD | 18687167, 21151198, 24311107 | |
| PA446214 | Osteoporosis, Postmenopausal | Disease | ClinicalAnnotation | associated | PD | 18687167, 21151198 | |
| PA448500 | atorvastatin | Chemical | ClinicalAnnotation | associated | PD | 21151198, 24311107 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38891810 | 2024 | Farnesyl Diphosphate Synthase Gene Associated with Loss of Bone Mass Density and Alendronate Treatment Failure in Patients with Primary Osteoporosis. | 0 |
| 38891810 | 2024 | Farnesyl Diphosphate Synthase Gene Associated with Loss of Bone Mass Density and Alendronate Treatment Failure in Patients with Primary Osteoporosis. | 0 |
| 37310396 | 2023 | Farnesyl diphosphate synthase exacerbates nonalcoholic steatohepatitis via the activation of AHR-CD36 axis. | 1 |
| 37310396 | 2023 | Farnesyl diphosphate synthase exacerbates nonalcoholic steatohepatitis via the activation of AHR-CD36 axis. | 1 |
| 34751146 | 2021 | Novel missense mutations of MVK and FDPS gene in Chinese patients with disseminated superficial actinic porokeratosis. | 2 |
| 34885721 | 2021 | Towards an Improvement of Anticancer Activity of Benzyl Adenosine Analogs. | 0 |
| 34751146 | 2021 | Novel missense mutations of MVK and FDPS gene in Chinese patients with disseminated superficial actinic porokeratosis. | 2 |
| 34885721 | 2021 | Towards an Improvement of Anticancer Activity of Benzyl Adenosine Analogs. | 0 |
| 30561051 | 2019 | A novel premature termination mutation in FDPS in a Chinese family with disseminated superficial actinic porokeratosis. | 1 |
| 30914801 | 2019 | FDPS cooperates with PTEN loss to promote prostate cancer progression through modulation of small GTPases/AKT axis. | 31 |
| 31774873 | 2019 | Polymorphisms of FDPS, LRP5, SOST and VKORC1 genes and their relation with osteoporosis in postmenopausal Romanian women. | 7 |
| 30561051 | 2019 | A novel premature termination mutation in FDPS in a Chinese family with disseminated superficial actinic porokeratosis. | 1 |
| 30914801 | 2019 | FDPS cooperates with PTEN loss to promote prostate cancer progression through modulation of small GTPases/AKT axis. | 31 |
| 31774873 | 2019 | Polymorphisms of FDPS, LRP5, SOST and VKORC1 genes and their relation with osteoporosis in postmenopausal Romanian women. | 7 |
| 29337059 | 2018 | FPPS mediates TGF-β1-induced non-small cell lung cancer cell invasion and the EMT process via the RhoA/Rock1 pathway. | 17 |
Citation
Dessen P
FDPS (farnesyl diphosphate synthase)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/43907/fdps
