CHIT1 (chitinase 1)

2007-02-01  

Identity

HGNC
CHIT1
LOCATION
1q32.1
LOCUSID
1118
ALIAS
CHI3,CHIT,CHITD
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1118
MIM: 600031
HGNC: 1936
Ensembl: ENSG00000133063

Variants:

dbSNP: 1118
ClinVar: 1118
TCGA: ENSG00000133063
COSMIC: CHIT1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000133063ENST00000255427Q13231
ENSG00000133063ENST00000367229Q13231
ENSG00000133063ENST00000491855Q13231
ENSG00000133063ENST00000503786D6REY1

Expression (GTEx)

0
1
2
3
4
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Amino sugar and nucleotide sugar metabolismKEGGko00520
Amino sugar and nucleotide sugar metabolismKEGGhsa00520
Metabolic pathwaysKEGGhsa01100
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
346370322022Increased Plasma YKL-40 Level and Chitotriosidase Activity in Cystic Fibrosis Patients.1
352223692022Longitudinal and Comparative Measures of Serum Chitotriosidase and YKL-40 in Patients With Idiopathic Pulmonary Fibrosis.9
363326932022Differential Glial Chitotriosidase 1 and Chitinase 3-like Protein 1 Expression in the Human Primary Visual Cortex and Cerebellum after Global Hypoxia-Ischemia.1
346370322022Increased Plasma YKL-40 Level and Chitotriosidase Activity in Cystic Fibrosis Patients.1
352223692022Longitudinal and Comparative Measures of Serum Chitotriosidase and YKL-40 in Patients With Idiopathic Pulmonary Fibrosis.9
363326932022Differential Glial Chitotriosidase 1 and Chitinase 3-like Protein 1 Expression in the Human Primary Visual Cortex and Cerebellum after Global Hypoxia-Ischemia.1
333070632021Chitotriosidase gene polymorphisms and mutations limit the determination of chitotriosidase expression in sarcoidosis.4
335762522021Chitotriosidase as biomarker for early stage amyotrophic lateral sclerosis: a multicenter study.8
338199752021A novel marker of systemic inflammation in psoriasis and related comorbidities: chitotriosidase.2
343210672021Increased chitotriosidase 1 concentration following nusinersen treatment in spinal muscular atrophy.8
345795122021Serum chitotriosidase and YKL-40 in acute pancreatitis: Reliability as prognostic marker for disease severity and correlation with inflammatory markers.1
347898992021Cardiopharyngeal deconstruction and ancestral tunicate sessility.8
333070632021Chitotriosidase gene polymorphisms and mutations limit the determination of chitotriosidase expression in sarcoidosis.4
335762522021Chitotriosidase as biomarker for early stage amyotrophic lateral sclerosis: a multicenter study.8
338199752021A novel marker of systemic inflammation in psoriasis and related comorbidities: chitotriosidase.2

Citation

Dessen P

CHIT1 (chitinase 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43912/gene-explorer/teaching-explorer/js/lib/jquery-3.5.1.min.js