CANX (calnexin)

2007-02-01 Affiliation

Identity

HGNC

CANX

LOCATION

5q35.3

LOCUSID

821

ALIAS

CNX,IP90,P90

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 821
MIM: 114217
HGNC: 1473
Ensembl: ENSG00000127022

Variants:

dbSNP: 821
ClinVar: 821
TCGA: ENSG00000127022
COSMIC: CANX

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000127022	ENST00000247461	P27824
ENSG00000127022	ENST00000452673	P27824
ENSG00000127022	ENST00000502296	D6RAU8
ENSG00000127022	ENST00000502498	D6RDP7
ENSG00000127022	ENST00000502673	D6RGY2
ENSG00000127022	ENST00000504579	D6RG29
ENSG00000127022	ENST00000504734	P27824
ENSG00000127022	ENST00000506654	D6RFL1
ENSG00000127022	ENST00000507307	D6RHJ3
ENSG00000127022	ENST00000508787	H0Y9H1
ENSG00000127022	ENST00000509563	D6RFW4
ENSG00000127022	ENST00000510810	H0Y9Q7
ENSG00000127022	ENST00000513246	D6RAQ8
ENSG00000127022	ENST00000514032	D6RD16
ENSG00000127022	ENST00000514383	D6RB85

Expression (GTEx)

100

150

200

250

300

350

400

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Antigen processing and presentation	KEGG	ko04612
Antigen processing and presentation	KEGG	hsa04612
Phagosome	KEGG	ko04145
Phagosome	KEGG	hsa04145
Protein processing in endoplasmic reticulum	KEGG	ko04141
Protein processing in endoplasmic reticulum	KEGG	hsa04141
HTLV-I infection	KEGG	ko05166
HTLV-I infection	KEGG	hsa05166
Thyroid hormone synthesis	KEGG	hsa04918
Thyroid hormone synthesis	KEGG	ko04918
Metabolism of proteins	REACTOME	R-HSA-392499
Post-translational protein modification	REACTOME	R-HSA-597592
Asparagine N-linked glycosylation	REACTOME	R-HSA-446203
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	REACTOME	R-HSA-532668
Calnexin/calreticulin cycle	REACTOME	R-HSA-901042
Disease	REACTOME	R-HSA-1643685
Infectious disease	REACTOME	R-HSA-5663205
Influenza Infection	REACTOME	R-HSA-168254
Influenza Life Cycle	REACTOME	R-HSA-168255
Virus Assembly and Release	REACTOME	R-HSA-168268
Assembly of Viral Components at the Budding Site	REACTOME	R-HSA-168316
Immune System	REACTOME	R-HSA-168256
Adaptive Immune System	REACTOME	R-HSA-1280218
Class I MHC mediated antigen processing & presentation	REACTOME	R-HSA-983169
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	REACTOME	R-HSA-983170
MHC class II antigen presentation	REACTOME	R-HSA-2132295

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
36840500	2023	PON2 ameliorates Ang II-induced cardiomyocyte injury by targeting the CANX/NOX4 signaling pathway.	1
36840500	2023	PON2 ameliorates Ang II-induced cardiomyocyte injury by targeting the CANX/NOX4 signaling pathway.	1
35266843	2022	KAT7-mediated CANX (calnexin) crotonylation regulates leucine-stimulated MTORC1 activity.	2
35266843	2022	KAT7-mediated CANX (calnexin) crotonylation regulates leucine-stimulated MTORC1 activity.	2
33562550	2021	The Role of Cardiolipin as a Scaffold Mitochondrial Phospholipid in Autophagosome Formation: In Vitro Evidence.	13
34064874	2021	Ca(2+) Regulates ERp57-Calnexin Complex Formation.	4
34135428	2021	Circulating small extracellular vesicles increase after an acute bout of moderate-intensity exercise in pregnant compared to non-pregnant women.	6
34603342	2021	A Chaperone-Like Role for EBI3 in Collaboration With Calnexin Under Inflammatory Conditions.	3
33562550	2021	The Role of Cardiolipin as a Scaffold Mitochondrial Phospholipid in Autophagosome Formation: In Vitro Evidence.	13
34064874	2021	Ca(2+) Regulates ERp57-Calnexin Complex Formation.	4
34135428	2021	Circulating small extracellular vesicles increase after an acute bout of moderate-intensity exercise in pregnant compared to non-pregnant women.	6
34603342	2021	A Chaperone-Like Role for EBI3 in Collaboration With Calnexin Under Inflammatory Conditions.	3
32967966	2020	Calnexin mediates the maturation of GPI-anchors through ER retention.	9
33077910	2020	ER-resident oxidoreductases are glycosylated and trafficked to the cell surface to promote matrix degradation by tumour cells.	12
32967966	2020	Calnexin mediates the maturation of GPI-anchors through ER retention.	9

Citation

Dessen P

CANX (calnexin)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43915/js/lib/tumors-explorer/cancer-prone-explorer/