ARG1 (arginase 1)

2007-02-01  

Identity

HGNC
ARG1
LOCATION
6q23.2
LOCUSID
383
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 383
MIM: 608313
HGNC: 663
Ensembl: ENSG00000118520

Variants:

dbSNP: 383
ClinVar: 383
TCGA: ENSG00000118520
COSMIC: ARG1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000118520ENST00000356962P05089
ENSG00000118520ENST00000368087P05089
ENSG00000118520ENST00000640973P05089

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Arginine biosynthesisKEGGko00220
Arginine and proline metabolismKEGGko00330
Arginine biosynthesisKEGGhsa00220
Arginine and proline metabolismKEGGhsa00330
Metabolic pathwaysKEGGhsa01100
AmoebiasisKEGGko05146
AmoebiasisKEGGhsa05146
Urea cycleKEGGhsa_M00029
Polyamine biosynthesis, arginine => ornithine => putrescineKEGGhsa_M00134
Urea cycleKEGGM00029
Polyamine biosynthesis, arginine => ornithine => putrescineKEGGM00134
Biosynthesis of amino acidsKEGGhsa01230
Biosynthesis of amino acidsKEGGko01230
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Urea cycleREACTOMER-HSA-70635
Metabolism of polyaminesREACTOMER-HSA-351202
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA134687887selective beta-2-adrenoreceptor agonistsChemicalClinicalAnnotationassociatedPD
PA166176020sodium benzoate / sodium phenylacetateChemicalLabelAnnotationassociated
PA443450AsthmaDiseaseClinicalAnnotationassociatedPD

References

Pubmed IDYearTitleCitations
379967002024DDR2-regulated arginase activity in ovarian cancer-associated fibroblasts promotes collagen production and tumor progression.4
383691882024Quantitative Multiplexed Analysis of Indoleamine 2,3-Dioxygenase (IDO) and Arginase-1 (ARG1) Expression and Myeloid Cell Infiltration in Colorectal Cancer.0
383741902024Arginase-induced cell death pathways and metabolic changes in cancer cells are not altered by insulin.0
379967002024DDR2-regulated arginase activity in ovarian cancer-associated fibroblasts promotes collagen production and tumor progression.4
383691882024Quantitative Multiplexed Analysis of Indoleamine 2,3-Dioxygenase (IDO) and Arginase-1 (ARG1) Expression and Myeloid Cell Infiltration in Colorectal Cancer.0
383741902024Arginase-induced cell death pathways and metabolic changes in cancer cells are not altered by insulin.0
363092952023Pathophysiological correlation of arginase-1 in development of type 2 diabetes from obesity in adolescents.0
365243152023Arginase-1+ bone marrow myeloid cells are reduced in myeloproliferative neoplasms and correlate with clinical phenotype, fibrosis, and molecular driver.5
367278492023Arginase 1 is a key driver of immune suppression in pancreatic cancer.22
377234902023Arginase-1 promotes lens epithelial-to-mesenchymal transition in different models of anterior subcapsular cataract.0
363092952023Pathophysiological correlation of arginase-1 in development of type 2 diabetes from obesity in adolescents.0
365243152023Arginase-1+ bone marrow myeloid cells are reduced in myeloproliferative neoplasms and correlate with clinical phenotype, fibrosis, and molecular driver.5
367278492023Arginase 1 is a key driver of immune suppression in pancreatic cancer.22
377234902023Arginase-1 promotes lens epithelial-to-mesenchymal transition in different models of anterior subcapsular cataract.0
349025072022Expression dynamics of the immune mediators ARG1, TBET, CIITA, IL10 and TGFB1 in chronic myeloid leukaemia patients during the first year of imatinib therapy.0

Citation

Dessen P

ARG1 (arginase 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43917/cancer-prone-explorer/css/gene-fusions-explorer/