ARG1 (arginase 1)

2007-02-01  

Identity

HGNC
LOCATION
6q23.2
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 383
MIM: 608313
HGNC: 663
Ensembl: ENSG00000118520

Variants:

dbSNP: 383
ClinVar: 383
TCGA: ENSG00000118520
COSMIC: ARG1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000118520ENST00000356962P05089
ENSG00000118520ENST00000368087P05089
ENSG00000118520ENST00000640973P05089

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450

Pathways

PathwaySourceExternal ID
Arginine biosynthesisKEGGko00220
Arginine and proline metabolismKEGGko00330
Arginine biosynthesisKEGGhsa00220
Arginine and proline metabolismKEGGhsa00330
Metabolic pathwaysKEGGhsa01100
AmoebiasisKEGGko05146
AmoebiasisKEGGhsa05146
Urea cycleKEGGhsa_M00029
Polyamine biosynthesis, arginine => ornithine => putrescineKEGGhsa_M00134
Urea cycleKEGGM00029
Polyamine biosynthesis, arginine => ornithine => putrescineKEGGM00134
Biosynthesis of amino acidsKEGGhsa01230
Biosynthesis of amino acidsKEGGko01230
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Urea cycleREACTOMER-HSA-70635
Metabolism of polyaminesREACTOMER-HSA-351202
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA134687887selective beta-2-adrenoreceptor agonistsChemicalClinicalAnnotationassociatedPD
PA166176020sodium benzoate / sodium phenylacetateChemicalLabelAnnotationassociated
PA443450AsthmaDiseaseClinicalAnnotationassociatedPD

References

Pubmed IDYearTitleCitations
379967002024DDR2-regulated arginase activity in ovarian cancer-associated fibroblasts promotes collagen production and tumor progression.4
383691882024Quantitative Multiplexed Analysis of Indoleamine 2,3-Dioxygenase (IDO) and Arginase-1 (ARG1) Expression and Myeloid Cell Infiltration in Colorectal Cancer.0
383741902024Arginase-induced cell death pathways and metabolic changes in cancer cells are not altered by insulin.0
379967002024DDR2-regulated arginase activity in ovarian cancer-associated fibroblasts promotes collagen production and tumor progression.4
383691882024Quantitative Multiplexed Analysis of Indoleamine 2,3-Dioxygenase (IDO) and Arginase-1 (ARG1) Expression and Myeloid Cell Infiltration in Colorectal Cancer.0
383741902024Arginase-induced cell death pathways and metabolic changes in cancer cells are not altered by insulin.0
363092952023Pathophysiological correlation of arginase-1 in development of type 2 diabetes from obesity in adolescents.0
365243152023Arginase-1+ bone marrow myeloid cells are reduced in myeloproliferative neoplasms and correlate with clinical phenotype, fibrosis, and molecular driver.5
367278492023Arginase 1 is a key driver of immune suppression in pancreatic cancer.22
377234902023Arginase-1 promotes lens epithelial-to-mesenchymal transition in different models of anterior subcapsular cataract.0
363092952023Pathophysiological correlation of arginase-1 in development of type 2 diabetes from obesity in adolescents.0
365243152023Arginase-1+ bone marrow myeloid cells are reduced in myeloproliferative neoplasms and correlate with clinical phenotype, fibrosis, and molecular driver.5
367278492023Arginase 1 is a key driver of immune suppression in pancreatic cancer.22
377234902023Arginase-1 promotes lens epithelial-to-mesenchymal transition in different models of anterior subcapsular cataract.0
349025072022Expression dynamics of the immune mediators ARG1, TBET, CIITA, IL10 and TGFB1 in chronic myeloid leukaemia patients during the first year of imatinib therapy.0

Citation

Dessen P

ARG1 (arginase 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43917/cancer-prone-explorer/js/favicon/favicon-16x16.png