CS (citrate synthase)

2007-02-01  

Identity

HGNC
CS
LOCATION
12q13.3
LOCUSID
1431
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1431
MIM: 118950
HGNC: 2422
Ensembl: ENSG00000062485

Variants:

dbSNP: 1431
ClinVar: 1431
TCGA: ENSG00000062485
COSMIC: CS

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000062485ENST00000351328O75390
ENSG00000062485ENST00000351328A0A024RB75
ENSG00000062485ENST00000542324B4DJV2
ENSG00000062485ENST00000546891H0YH82
ENSG00000062485ENST00000546930F8VR34
ENSG00000062485ENST00000547298F8VRP1
ENSG00000062485ENST00000548041F8VTT8
ENSG00000062485ENST00000548567A0A0C4DGI3
ENSG00000062485ENST00000548746H0YIC4
ENSG00000062485ENST00000548849F8VWQ5
ENSG00000062485ENST00000549143F8VVY4
ENSG00000062485ENST00000549221F8VRI6
ENSG00000062485ENST00000550159F8VZK9
ENSG00000062485ENST00000550655F8W4S1
ENSG00000062485ENST00000550734F8VPA1
ENSG00000062485ENST00000551137F8VX07
ENSG00000062485ENST00000551253F8VPF9
ENSG00000062485ENST00000551430F8W642
ENSG00000062485ENST00000551473F8VX68
ENSG00000062485ENST00000551936F8VPA1
ENSG00000062485ENST00000551968F8VU34
ENSG00000062485ENST00000552222F8W0J2
ENSG00000062485ENST00000552688F8W1S4

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Citrate cycle (TCA cycle)KEGGko00020
Glyoxylate and dicarboxylate metabolismKEGGko00630
Citrate cycle (TCA cycle)KEGGhsa00020
Glyoxylate and dicarboxylate metabolismKEGGhsa00630
Metabolic pathwaysKEGGhsa01100
Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarateKEGGhsa_M00010
Citrate cycle (TCA cycle, Krebs cycle)KEGGM00009
Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarateKEGGM00010
2-Oxocarboxylic acid metabolismKEGGhsa01210
2-Oxocarboxylic acid metabolismKEGGko01210
Biosynthesis of amino acidsKEGGhsa01230
Biosynthesis of amino acidsKEGGko01230
Carbon metabolismKEGGhsa01200
Carbon metabolismKEGGko01200
Citrate cycle (TCA cycle, Krebs cycle)KEGGhsa_M00009
Metabolism of proteinsREACTOMER-HSA-392499
Mitochondrial protein importREACTOMER-HSA-1268020
MetabolismREACTOMER-HSA-1430728
The citric acid (TCA) cycle and respiratory electron transportREACTOMER-HSA-1428517
Pyruvate metabolism and Citric Acid (TCA) cycleREACTOMER-HSA-71406
Citric acid cycle (TCA cycle)REACTOMER-HSA-71403

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
384211062024Citrate synthase lysine K215 hypoacetylation contributes to microglial citrate accumulation and pro-inflammatory functions after traumatic brain injury.0
384211062024Citrate synthase lysine K215 hypoacetylation contributes to microglial citrate accumulation and pro-inflammatory functions after traumatic brain injury.0
363503742023The left-lateralisation of citrate synthase activity in the anterior cingulate cortex of male violent suicide victims.0
373934922023The Novel Role of Mitochondrial Citrate Synthase and Citrate in the Pathophysiology of Alzheimer's Disease.8
363503742023The left-lateralisation of citrate synthase activity in the anterior cingulate cortex of male violent suicide victims.0
373934922023The Novel Role of Mitochondrial Citrate Synthase and Citrate in the Pathophysiology of Alzheimer's Disease.8
334353502021Rethinking the Citric Acid Cycle: Connecting Pyruvate Carboxylase and Citrate Synthase to the Flow of Energy and Material.14
334353502021Rethinking the Citric Acid Cycle: Connecting Pyruvate Carboxylase and Citrate Synthase to the Flow of Energy and Material.14
311414752019Comparative studies of Aspergillus fumigatus 2-methylcitrate synthase and human citrate synthase.4
311414752019Comparative studies of Aspergillus fumigatus 2-methylcitrate synthase and human citrate synthase.4
281616432017SIRT3 deacetylated and increased citrate synthase activity in PD model.26
282161612017Reduced expression of citrate synthase leads to excessive superoxide formation and cell apoptosis.19
283915952017Human METTL12 is a mitochondrial methyltransferase that modifies citrate synthase.19
288873082017Uncovering human METTL12 as a mitochondrial methyltransferase that modulates citrate synthase activity through metabolite-sensitive lysine methylation.17
281616432017SIRT3 deacetylated and increased citrate synthase activity in PD model.26

Citation

Dessen P

CS (citrate synthase)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43924