GLO1 (glyoxalase I)

2007-02-01  

Identity

HGNC
LOCATION
6p21.2
LOCUSID
ALIAS
GLOD1,GLYI,HEL-S-74
FUSION GENES

Other Information

Locus ID:

NCBI: 2739
MIM: 138750
HGNC: 4323
Ensembl: ENSG00000124767

Variants:

dbSNP: 2739
ClinVar: 2739
TCGA: ENSG00000124767
COSMIC: GLO1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000124767ENST00000373365Q04760
ENSG00000124767ENST00000373365X5DNM4

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Pyruvate metabolismKEGGko00620
Pyruvate metabolismKEGGhsa00620
MetabolismREACTOMER-HSA-1430728
The citric acid (TCA) cycle and respiratory electron transportREACTOMER-HSA-1428517
Pyruvate metabolism and Citric Acid (TCA) cycleREACTOMER-HSA-71406
Pyruvate metabolismREACTOMER-HSA-70268

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
388701762024Glyoxalase 1: Emerging biomarker and therapeutic target in cervical cancer progression.0
388701762024Glyoxalase 1: Emerging biomarker and therapeutic target in cervical cancer progression.0
365767002023H3K27 acetylation activated long noncoding RNA RP11-162G10.5 promotes breast cancer progression via the YBX1/GLO1 axis.3
375728002023The genetic polymorphisms and activity of glyoxalase 1 as a risk factor for acute coronary syndrome in South Indians with type 2 diabetes mellitus.2
378142052023MiR-205-3p suppresses bladder cancer progression via GLO1 mediated P38/ERK activation.0
380271262023Association between GLO1 variants and gestational diabetes mellitus susceptibility in a Chinese population: a preliminary study.1
365767002023H3K27 acetylation activated long noncoding RNA RP11-162G10.5 promotes breast cancer progression via the YBX1/GLO1 axis.3
375728002023The genetic polymorphisms and activity of glyoxalase 1 as a risk factor for acute coronary syndrome in South Indians with type 2 diabetes mellitus.2
378142052023MiR-205-3p suppresses bladder cancer progression via GLO1 mediated P38/ERK activation.0
380271262023Association between GLO1 variants and gestational diabetes mellitus susceptibility in a Chinese population: a preliminary study.1
317380282022High expression of GLO1 indicates unfavorable clinical outcomes in glioma patients.2
348387142022The activity of glyoxylase 1 is regulated by glucose-responsive phosphorylation on Tyr136.3
352695942022Emerging Glycation-Based Therapeutics-Glyoxalase 1 Inducers and Glyoxalase 1 Inhibitors.14
317380282022High expression of GLO1 indicates unfavorable clinical outcomes in glioma patients.2
348387142022The activity of glyoxylase 1 is regulated by glucose-responsive phosphorylation on Tyr136.3

Citation

Dessen P

GLO1 (glyoxalase I)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43930/glo1