PDHX (pyruvate dehydrogenase complex component X)

2007-02-01  

Identity

HGNC
PDHX
LOCATION
11p13
LOCUSID
8050
ALIAS
DLDBP,E3BP,OPDX,PDHXD,PDX1,proX
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8050
MIM: 608769
HGNC: 21350
Ensembl: ENSG00000110435

Variants:

dbSNP: 8050
ClinVar: 8050
TCGA: ENSG00000110435
COSMIC: PDHX

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000110435ENST00000227868O00330
ENSG00000110435ENST00000430469O00330
ENSG00000110435ENST00000448838O00330
ENSG00000110435ENST00000526309H0YD97
ENSG00000110435ENST00000533262E9PRI6
ENSG00000110435ENST00000533550E9PLU0

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolic pathwaysKEGGhsa01100
Signal TransductionREACTOMER-HSA-162582
Signaling by Retinoic AcidREACTOMER-HSA-5362517
MetabolismREACTOMER-HSA-1430728
The citric acid (TCA) cycle and respiratory electron transportREACTOMER-HSA-1428517
Pyruvate metabolism and Citric Acid (TCA) cycleREACTOMER-HSA-71406
Pyruvate metabolismREACTOMER-HSA-70268
Regulation of pyruvate dehydrogenase (PDH) complexREACTOMER-HSA-204174
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Glyoxylate metabolism and glycine degradationREACTOMER-HSA-389661

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
368891942023Cuproptosis-related gene PDHX and heat stress-related HSPD1 as potential key drivers associated with cell stemness, aberrant metabolism and immunosuppression in esophageal carcinoma.1
368891942023Cuproptosis-related gene PDHX and heat stress-related HSPD1 as potential key drivers associated with cell stemness, aberrant metabolism and immunosuppression in esophageal carcinoma.1
339640392021Identification of PDHX as a metabolic target for esophageal squamous cell carcinoma.7
339640392021Identification of PDHX as a metabolic target for esophageal squamous cell carcinoma.7
300121702018Suppression of PDHX by microRNA-27b deregulates cell metabolism and promotes growth in breast cancer.37
300121702018Suppression of PDHX by microRNA-27b deregulates cell metabolism and promotes growth in breast cancer.37
249352202014MicroRNA-26a regulates glucose metabolism by direct targeting PDHX in colorectal cancer cells.63
250871642014Founder p.Arg 446* mutation in the PDHX gene explains over half of cases with congenital lactic acidosis in Roma children.7
249352202014MicroRNA-26a regulates glucose metabolism by direct targeting PDHX in colorectal cancer cells.63
250871642014Founder p.Arg 446* mutation in the PDHX gene explains over half of cases with congenital lactic acidosis in Roma children.7
227660022012Pyruvate dehydrogenase deficiency caused by a new mutation of PDHX gene in two Moroccan patients.6
227660022012Pyruvate dehydrogenase deficiency caused by a new mutation of PDHX gene in two Moroccan patients.6
211946772011Identification of a systemic lupus erythematosus susceptibility locus at 11p13 between PDHX and CD44 in a multiethnic study.45
211946772011Identification of a systemic lupus erythematosus susceptibility locus at 11p13 between PDHX and CD44 in a multiethnic study.45
208006032010Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.14

Citation

Dessen P

PDHX (pyruvate dehydrogenase complex component X)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43932