Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 2730
MIM: 601176
HGNC: 4312
Ensembl: ENSG00000023909
Variants:
dbSNP: 2730
ClinVar: 2730
TCGA: ENSG00000023909
COSMIC: GCLM
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000023909 | ENST00000370238 | P48507 |
| ENSG00000023909 | ENST00000615724 | P48507 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 35241341 | 2023 | Glutamate-cysteine ligase catalytic and its modifier function as novel immunotargets in gastric adenocarcinoma. | 3 |
| 35241341 | 2023 | Glutamate-cysteine ligase catalytic and its modifier function as novel immunotargets in gastric adenocarcinoma. | 3 |
| 34642912 | 2022 | Association of Polymorphisms of Glutamate Cysteine Ligase Genes GCLC C-129 T and GCLM C-588 T with Risk of Polycystic Ovary Syndrome in Chinese Women. | 3 |
| 34642912 | 2022 | Association of Polymorphisms of Glutamate Cysteine Ligase Genes GCLC C-129 T and GCLM C-588 T with Risk of Polycystic Ovary Syndrome in Chinese Women. | 3 |
| 33421846 | 2021 | Association of glutamate cystein ligase (GCL) activity Peroxiredoxin 4 (prxR4) and apelin levels in women with preeclampsia. | 4 |
| 33421846 | 2021 | Association of glutamate cystein ligase (GCL) activity Peroxiredoxin 4 (prxR4) and apelin levels in women with preeclampsia. | 4 |
| 32715377 | 2020 | Genetic variants in glutamate cysteine ligase confer protection against type 2 diabetes. | 7 |
| 32715377 | 2020 | Genetic variants in glutamate cysteine ligase confer protection against type 2 diabetes. | 7 |
| 28757675 | 2017 | Association of GCLM -588C/T and GCLC -129T/C Promoter Polymorphisms of Genes Coding the Subunits of Glutamate Cysteine Ligase with Ischemic Heart Disease Development in Kazakhstan Population. | 5 |
| 28993271 | 2017 | Temporal changes in glutathione biosynthesis during the lipopolysaccharide-induced inflammatory response of THP-1 macrophages. | 12 |
| 28757675 | 2017 | Association of GCLM -588C/T and GCLC -129T/C Promoter Polymorphisms of Genes Coding the Subunits of Glutamate Cysteine Ligase with Ischemic Heart Disease Development in Kazakhstan Population. | 5 |
| 28993271 | 2017 | Temporal changes in glutathione biosynthesis during the lipopolysaccharide-induced inflammatory response of THP-1 macrophages. | 12 |
| 26507778 | 2016 | Aged garlic extract enhances heme oxygenase-1 and glutamate-cysteine ligase modifier subunit expression via the nuclear factor erythroid 2-related factor 2-antioxidant response element signaling pathway in human endothelial cells. | 21 |
| 26520442 | 2016 | HNF1β drives glutathione (GSH) synthesis underlying intrinsic carboplatin resistance of ovarian clear cell carcinoma (OCCC). | 30 |
| 26894974 | 2016 | Nrf2 is the key to chemotherapy resistance in MCF7 breast cancer cells under hypoxia. | 51 |
Citation
Dessen P
GCLM (glutamate-cysteine ligase modifier subunit)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/43938/gclm
