HHIP (hedgehog interacting protein)

2007-02-01  

Identity

HGNC
HHIP
LOCATION
4q31.21
LOCUSID
64399
ALIAS
HIP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 64399
MIM: 606178
HGNC: 14866
Ensembl: ENSG00000164161

Variants:

dbSNP: 64399
ClinVar: 64399
TCGA: ENSG00000164161
COSMIC: HHIP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164161ENST00000296575Q96QV1
ENSG00000164161ENST00000434550Q96QV1

Expression (GTEx)

0
1
2
3
4
5
6
7
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Hedgehog signaling pathwayKEGGko04340
Basal cell carcinomaKEGGko05217
Hedgehog signaling pathwayKEGGhsa04340
Pathways in cancerKEGGhsa05200
Basal cell carcinomaKEGGhsa05217
cAMP signaling pathwayKEGGhsa04024
cAMP signaling pathwayKEGGko04024
Signal TransductionREACTOMER-HSA-162582
Signaling by HedgehogREACTOMER-HSA-5358351
Hedgehog 'on' stateREACTOMER-HSA-5632684
Ligand-receptor interactionsREACTOMER-HSA-5632681

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
384173782024Identification of a distal enhancer regulating hedgehog interacting protein gene in human lung epithelial cells.1
384173782024Identification of a distal enhancer regulating hedgehog interacting protein gene in human lung epithelial cells.1
350378182022Association of human Hedgehog interacting protein gene polymorphisms with the risk of chronic obstructive pulmonary disease: a meta-analysis.0
352766082022Differential promoter usages of PTCH1 and down regulation of HHIP are associated with HNSCC progression.1
363748122022Natural Antisense Long Noncoding RNA HHIP-AS1 Suppresses Non-Small-Cell Lung Cancer Progression by Increasing HHIP Stability via Interaction with CELF2.3
364823252022Exosomal microRNAs in the DLK1-DIO3 imprinted region derived from cancer-associated fibroblasts promote progression of hepatocellular carcinoma by targeting hedgehog interacting protein.3
350378182022Association of human Hedgehog interacting protein gene polymorphisms with the risk of chronic obstructive pulmonary disease: a meta-analysis.0
352766082022Differential promoter usages of PTCH1 and down regulation of HHIP are associated with HNSCC progression.1
363748122022Natural Antisense Long Noncoding RNA HHIP-AS1 Suppresses Non-Small-Cell Lung Cancer Progression by Increasing HHIP Stability via Interaction with CELF2.3
364823252022Exosomal microRNAs in the DLK1-DIO3 imprinted region derived from cancer-associated fibroblasts promote progression of hepatocellular carcinoma by targeting hedgehog interacting protein.3
327106112021Downregulation of hedgehog-interacting protein (HHIP) contributes to hexavalent chromium-induced malignant transformation of human bronchial epithelial cells.6
339072312021Hedgehog interacting protein (HHIP) represses airway remodeling and metabolic reprogramming in COPD-derived airway smooth muscle cells.11
346432452021Long non‑coding RNA HHIP‑AS1 inhibits lung cancer epithelial‑mesenchymal transition and stemness by regulating PCDHGA9.1
348874032021Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling.12
327106112021Downregulation of hedgehog-interacting protein (HHIP) contributes to hexavalent chromium-induced malignant transformation of human bronchial epithelial cells.6

Citation

Dessen P

HHIP (hedgehog interacting protein)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43958