IL15RA (interleukin 15 receptor subunit alpha)

2007-02-01  

Identity

HGNC
IL15RA
LOCATION
10p15.1
LOCUSID
3601
ALIAS
CD215

Other Information

Locus ID:

NCBI: 3601
MIM: 601070
HGNC: 5978
Ensembl: ENSG00000134470

Variants:

dbSNP: 3601
ClinVar: 3601
TCGA: ENSG00000134470
COSMIC: IL15RA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000134470ENST00000379971Q13261
ENSG00000134470ENST00000379977Q13261
ENSG00000134470ENST00000397246E7ETI1
ENSG00000134470ENST00000397248A0A0A0MS77
ENSG00000134470ENST00000397250Q13261
ENSG00000134470ENST00000397251K9N1J3
ENSG00000134470ENST00000397255Q13261
ENSG00000134470ENST00000429135E9PQ64
ENSG00000134470ENST00000435171H0Y4R3
ENSG00000134470ENST00000447291H0Y6E8
ENSG00000134470ENST00000453922Q5JVA3
ENSG00000134470ENST00000525219Q13261
ENSG00000134470ENST00000528354Q13261
ENSG00000134470ENST00000530685Q13261
ENSG00000134470ENST00000532039H0YD11
ENSG00000134470ENST00000620345K9N163
ENSG00000134470ENST00000620865K9N2S2
ENSG00000134470ENST00000622442K9N2Q6

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Jak-STAT signaling pathwayKEGGko04630
Cytokine-cytokine receptor interactionKEGGhsa04060
Jak-STAT signaling pathwayKEGGhsa04630
Intestinal immune network for IgA productionKEGGko04672
Intestinal immune network for IgA productionKEGGhsa04672
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
366072232023Structural basis for the mutation-induced dysfunction of the human IL-15/IL-15α receptor complex.0
366072232023Structural basis for the mutation-induced dysfunction of the human IL-15/IL-15α receptor complex.0
358572152022miRNA-binding site polymorphism in IL-15RA gene in rheumatoid arthritis and systemic lupus erythematosus: correlation with disease risk and clinical characteristics.2
358572152022miRNA-binding site polymorphism in IL-15RA gene in rheumatoid arthritis and systemic lupus erythematosus: correlation with disease risk and clinical characteristics.2
337322452021Thymic Epithelial Cell-Derived IL-15 and IL-15 Receptor α Chain Foster Local Environment for Type 1 Innate Like T Cell Development.4
337322452021Thymic Epithelial Cell-Derived IL-15 and IL-15 Receptor α Chain Foster Local Environment for Type 1 Innate Like T Cell Development.4
325001862020The expression levels of CHI3L1 and IL15Rα correlate with TGM2 in duodenum biopsies of patients with celiac disease.5
327672572020Tumor cell-expressed IL-15Rα drives antagonistic effects on the progression and immune control of gastric cancer and is epigenetically regulated in EBV-positive gastric cancer.2
327931942020IL-15 and IL15RA in Osteoarthritis: Association With Symptoms and Protease Production, but Not Structural Severity.11
331777362020RUNX2 and IL-15RA Polymorphisms associated with OPLL in the Han and Mongolian population.1
325001862020The expression levels of CHI3L1 and IL15Rα correlate with TGM2 in duodenum biopsies of patients with celiac disease.5
327672572020Tumor cell-expressed IL-15Rα drives antagonistic effects on the progression and immune control of gastric cancer and is epigenetically regulated in EBV-positive gastric cancer.2
327931942020IL-15 and IL15RA in Osteoarthritis: Association With Symptoms and Protease Production, but Not Structural Severity.11
331777362020RUNX2 and IL-15RA Polymorphisms associated with OPLL in the Han and Mongolian population.1
312444232019Schizophrenia Patient Shows a Rare Interleukin 15 Receptor alpha Variant Disrupting Signal Transduction.2

Citation

Dessen P

IL15RA (interleukin 15 receptor subunit alpha)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43964