Identity
HGNC
LOCATION
11p15.4
LOCUSID
ALIAS
RNF88,TRIM5alpha
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 85363
MIM: 608487
HGNC: 16276
Ensembl: ENSG00000132256
Variants:
dbSNP: 85363
ClinVar: 85363
TCGA: ENSG00000132256
COSMIC: TRIM5
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA166123207 | overall survival | Disease | VariantAnnotation | associated | PD | ||
| PA445204 | Ovarian Neoplasms | Disease | VariantAnnotation | associated | PD | ||
| PA448803 | carboplatin | Chemical | VariantAnnotation | associated | PD | ||
| PA450761 | paclitaxel | Chemical | VariantAnnotation | associated | PD |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37942942 | 2024 | The effect of TRIM5 variants on the susceptibility to HIV-1 infection and disease progression in the Polish population. | 0 |
| 38814780 | 2024 | TBK1 is ubiquitinated by TRIM5α to assemble mitophagy machinery. | 1 |
| 37942942 | 2024 | The effect of TRIM5 variants on the susceptibility to HIV-1 infection and disease progression in the Polish population. | 0 |
| 38814780 | 2024 | TBK1 is ubiquitinated by TRIM5α to assemble mitophagy machinery. | 1 |
| 35659190 | 2023 | The retroviral restriction factor TRIM5/TRIM5α regulates mitochondrial quality control. | 0 |
| 37180175 | 2023 | A frequent SNP in TRIM5α strongly enhances the innate immune response against LINE-1 elements. | 0 |
| 37558876 | 2023 | TRIM5α restricts poxviruses and is antagonized by CypA and the viral protein C6. | 8 |
| 35659190 | 2023 | The retroviral restriction factor TRIM5/TRIM5α regulates mitochondrial quality control. | 0 |
| 37180175 | 2023 | A frequent SNP in TRIM5α strongly enhances the innate immune response against LINE-1 elements. | 0 |
| 37558876 | 2023 | TRIM5α restricts poxviruses and is antagonized by CypA and the viral protein C6. | 8 |
| 35215956 | 2022 | TRIM5α Restriction of HIV-1-N74D Viruses in Lymphocytes Is Caused by a Loss of Cyclophilin A Protection. | 5 |
| 35545034 | 2022 | Interactomic analysis reveals a homeostatic role for the HIV restriction factor TRIM5α in mitophagy. | 11 |
| 35215956 | 2022 | TRIM5α Restriction of HIV-1-N74D Viruses in Lymphocytes Is Caused by a Loss of Cyclophilin A Protection. | 5 |
| 35545034 | 2022 | Interactomic analysis reveals a homeostatic role for the HIV restriction factor TRIM5α in mitophagy. | 11 |
| 33440192 | 2021 | Knockdown of TRIM5α or TRIM11 increases lentiviral vector transduction efficiency of human Muller cells. | 2 |
Citation
Dessen P
TRIM5 (tripartite motif containing 5)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/43965/trim5
