GABARAP (GABA type A receptor-associated protein)

2007-02-01  

Identity

HGNC
LOCATION
17p13.1
LOCUSID
ALIAS
ATG8A,GABARAP-a,MM46
FUSION GENES

Other Information

Locus ID:

NCBI: 11337
MIM: 605125
HGNC: 4067
Ensembl: ENSG00000170296

Variants:

dbSNP: 11337
ClinVar: 11337
TCGA: ENSG00000170296
COSMIC: GABARAP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000170296ENST00000302386O95166
ENSG00000170296ENST00000302386Q6IAW1
ENSG00000170296ENST00000570856I3L3J4
ENSG00000170296ENST00000571129I3L236
ENSG00000170296ENST00000571253I3L236
ENSG00000170296ENST00000573928H6UMI1
ENSG00000170296ENST00000577035I3L236

Expression (GTEx)

0
100
200
300
400
500
600
700

Pathways

PathwaySourceExternal ID
Autophagy - animalKEGGko04140
Autophagy - animalKEGGhsa04140
NOD-like receptor signaling pathwayKEGGko04621
NOD-like receptor signaling pathwayKEGGhsa04621
GABAergic synapseKEGGko04727
GABAergic synapseKEGGhsa04727
FoxO signaling pathwayKEGGhsa04068
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Cellular responses to stressREACTOMER-HSA-2262752
MacroautophagyREACTOMER-HSA-1632852
TBC/RABGAPsREACTOMER-HSA-8854214
Apelin signaling pathwayKEGGhsa04371
Mitophagy - animalKEGGko04137
Mitophagy - animalKEGGhsa04137
Autophagy - otherKEGGko04136
Autophagy - otherKEGGhsa04136

References

Pubmed IDYearTitleCitations
368983702023TNIP1 inhibits selective autophagy via bipartite interaction with LC3/GABARAP and TAX1BP1.9
374343642023ATG4B antagonizes antiviral immunity by GABARAP-directed autophagic degradation of TBK1.2
374786272023METTL3 promotes hyperoxia-induced pyroptosis in neonatal bronchopulmonary dysplasia by inhibiting ATG8-mediated autophagy.0
379874472023Microautophagy regulated by STK38 and GABARAPs is essential to repair lysosomes and prevent aging.3
368983702023TNIP1 inhibits selective autophagy via bipartite interaction with LC3/GABARAP and TAX1BP1.9
374343642023ATG4B antagonizes antiviral immunity by GABARAP-directed autophagic degradation of TBK1.2
374786272023METTL3 promotes hyperoxia-induced pyroptosis in neonatal bronchopulmonary dysplasia by inhibiting ATG8-mediated autophagy.0
379874472023Microautophagy regulated by STK38 and GABARAPs is essential to repair lysosomes and prevent aging.3
335919432021GABARAP suppresses EMT and breast cancer progression via the AKT/mTOR signaling pathway.9
335919432021GABARAP suppresses EMT and breast cancer progression via the AKT/mTOR signaling pathway.9
305048232020Ankyrin-G regulates forebrain connectivity and network synchronization via interaction with GABARAP.28
309824322020Human LC3 and GABARAP subfamily members achieve functional specificity via specific structural modulations.30
309903542020An atypical LIR motif within UBA5 (ubiquitin like modifier activating enzyme 5) interacts with GABARAP proteins and mediates membrane localization of UBA5.23
312082832020GABARAPs and LC3s have opposite roles in regulating ULK1 for autophagy induction.50
320092922020A conserved ATG2-GABARAP family interaction is critical for phagophore formation.41

Citation

Dessen P

GABARAP (GABA type A receptor-associated protein)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43973/gabarap