USP14 (ubiquitin specific peptidase 14)

2007-02-01  

Identity

HGNC
USP14
LOCATION
18p11.32
LOCUSID
9097
ALIAS
TGT
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9097
MIM: 607274
HGNC: 12612
Ensembl: ENSG00000101557

Variants:

dbSNP: 9097
ClinVar: 9097
TCGA: ENSG00000101557
COSMIC: USP14

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000101557ENST00000261601P54578
ENSG00000101557ENST00000383589A6NJA2
ENSG00000101557ENST00000400266P54578
ENSG00000101557ENST00000580410J3QQT6
ENSG00000101557ENST00000581983J3KS55
ENSG00000101557ENST00000582707P54578
ENSG00000101557ENST00000583119R4GNB0

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
DeubiquitinationREACTOMER-HSA-5688426
Ub-specific processing proteasesREACTOMER-HSA-5689880

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
380695652024USP14 promotes the proliferation of cervical cancer via upregulating β-catenin.0
380733822024The regulatory role and mechanism of USP14 in endothelial cell pyroptosis induced by coronary heart disease.0
382287152024GSTM3 enhances radiosensitivity of nasopharyngeal carcinoma by promoting radiation-induced ferroptosis through USP14/FASN axis and GPX4.0
383884302024Ubiquitin-specific protease 14 targets PFKL-mediated glycolysis to promote the proliferation and migration of oral squamous cell carcinoma.0
386315822024Mechanistic insights into the role of USP14 in adipose tissue macrophage recruitment and insulin resistance in obesity.0
388910872024Structural Dynamics Analysis of USP14 Activation by AKT-Mediated Phosphorylation.0
389935522024Deubiquitination of CIB1 by USP14 promotes lenvatinib resistance via the PAK1-ERK1/2 axis in hepatocellular carcinoma.0
380695652024USP14 promotes the proliferation of cervical cancer via upregulating β-catenin.0
380733822024The regulatory role and mechanism of USP14 in endothelial cell pyroptosis induced by coronary heart disease.0
382287152024GSTM3 enhances radiosensitivity of nasopharyngeal carcinoma by promoting radiation-induced ferroptosis through USP14/FASN axis and GPX4.0
383884302024Ubiquitin-specific protease 14 targets PFKL-mediated glycolysis to promote the proliferation and migration of oral squamous cell carcinoma.0
386315822024Mechanistic insights into the role of USP14 in adipose tissue macrophage recruitment and insulin resistance in obesity.0
388910872024Structural Dynamics Analysis of USP14 Activation by AKT-Mediated Phosphorylation.0
389935522024Deubiquitination of CIB1 by USP14 promotes lenvatinib resistance via the PAK1-ERK1/2 axis in hepatocellular carcinoma.0
363284852023Insulin Suppresses Ubiquitination via the Deubiquitinating Enzyme Ubiquitin-Specific Protease 14, Independent of Proteasome Activity in H4IIEC3 Hepatocytes.2

Citation

Dessen P

USP14 (ubiquitin specific peptidase 14)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43975