CYP2A13 (cytochrome P450 family 2 subfamily A member 13)

2007-02-01  

Identity

HGNC
CYP2A13
LOCATION
19q13.2
LOCUSID
1553
ALIAS
CPAD,CYP2A,CYPIIA13

Other Information

Locus ID:

NCBI: 1553
MIM: 608055
HGNC: 2608
Ensembl: ENSG00000197838

Variants:

dbSNP: 1553
ClinVar: 1553
TCGA: ENSG00000197838
COSMIC: CYP2A13

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000197838ENST00000330436Q16696

Expression (GTEx)

0
1
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of xenobiotics by cytochrome P450KEGGko00980
Metabolism of xenobiotics by cytochrome P450KEGGhsa00980
Chemical carcinogenesisKEGGhsa05204
Chemical carcinogenesisKEGGko05204
MetabolismREACTOMER-HSA-1430728
Biological oxidationsREACTOMER-HSA-211859
Phase 1 - Functionalization of compoundsREACTOMER-HSA-211945
Cytochrome P450 - arranged by substrate typeREACTOMER-HSA-211897
XenobioticsREACTOMER-HSA-211981
CYP2E1 reactionsREACTOMER-HSA-211999
Fatty acidsREACTOMER-HSA-211935
Aflatoxin activation and detoxificationREACTOMER-HSA-5423646

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA134521193coumarinChemicalVariantAnnotationassociatedPK29342418
PA166181759nnkChemicalVipGeneassociated
PA445876Tobacco Use DisorderDiseaseClinicalAnnotationassociatedPD
PA450626nicotineChemicalClinicalAnnotation, VariantAnnotationassociatedPKPD29342418

References

Pubmed IDYearTitleCitations
337039882021Molecular docking and oxidation kinetics of 3-phenyl coumarin derivatives by human CYP2A13.4
348301882021Genetic and Enzymatic Characteristics of CYP2A13 in Relation to Lung Damage.0
337039882021Molecular docking and oxidation kinetics of 3-phenyl coumarin derivatives by human CYP2A13.4
348301882021Genetic and Enzymatic Characteristics of CYP2A13 in Relation to Lung Damage.0
333272542020Association between CYP2A13 polymorphisms and lung cancer: A protocol for systematic review and meta-analysis.0
333272542020Association between CYP2A13 polymorphisms and lung cancer: A protocol for systematic review and meta-analysis.0
308076882019HapMap-based study: CYP2A13 may be a potential key metabolic enzyme gene in the carcinogenesis of lung cancer in non-smokers.3
308076882019HapMap-based study: CYP2A13 may be a potential key metabolic enzyme gene in the carcinogenesis of lung cancer in non-smokers.3
286481402018Oxidation of 1-chloropyrene by human CYP1 family and CYP2A subfamily cytochrome P450 enzymes: catalytic roles of two CYP1B1 and five CYP2A13 allelic variants.5
296522242018In vitro functional analysis of human cytochrome P450 2A13 genetic variants: P450 2A13*2, *3, *4, and *10.7
286481402018Oxidation of 1-chloropyrene by human CYP1 family and CYP2A subfamily cytochrome P450 enzymes: catalytic roles of two CYP1B1 and five CYP2A13 allelic variants.5
296522242018In vitro functional analysis of human cytochrome P450 2A13 genetic variants: P450 2A13*2, *3, *4, and *10.7
275675462016In vitro metabolism of N'-Nitrosonornicotine catalyzed by cytochrome P450 2A13 and its inhibition by nicotine, N'-Nitrosoanatabine and N'-Nitrosoanabasine.1
277254462016CYP2A13 Genetic Polymorphisms in Relation to the Risk of Bladder Cancer in Japanese Smokers.3
275675462016In vitro metabolism of N'-Nitrosonornicotine catalyzed by cytochrome P450 2A13 and its inhibition by nicotine, N'-Nitrosoanatabine and N'-Nitrosoanabasine.1

Citation

Dessen P

CYP2A13 (cytochrome P450 family 2 subfamily A member 13)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43982