SOX9 (SRY-box transcription factor 9)

2007-02-01  

Identity

HGNC
SOX9
LOCATION
17q24.3
LOCUSID
6662
ALIAS
CMD1,CMPD1,SRA1,SRXX2,SRXY10

Other Information

Locus ID:

NCBI: 6662
MIM: 608160
HGNC: 11204
Ensembl: ENSG00000125398

Variants:

dbSNP: 6662
ClinVar: 6662
TCGA: ENSG00000125398
COSMIC: SOX9

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000125398ENST00000245479P48436

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
cAMP signaling pathwayKEGGhsa04024
cAMP signaling pathwayKEGGko04024
Signal TransductionREACTOMER-HSA-162582
Signaling by WntREACTOMER-HSA-195721
TCF dependent signaling in response to WNTREACTOMER-HSA-201681
Deactivation of the beta-catenin transactivating complexREACTOMER-HSA-3769402

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
381796982024Sox9 Accelerates Vascular Aging by Regulating Extracellular Matrix Composition and Stiffness.4
382268372024Hypoxia promotes non-small cell lung cancer cell stemness, migration, and invasion via promoting glycolysis by lactylation of SOX9.3
382382882024Sox9 regulates alternative splicing and pancreatic beta cell function.0
382457672024SOX9 gene shows association with adolescent idiopathic scoliosis predisposition in Northwest Indians.0
382613972024LT and SOX9 expression are associated with gene sets that distinguish Merkel cell polyomavirus (MCPyV)-positive and MCPyV-negative Merkel cell carcinoma.0
383455522024SOX9 Induces Orbital Fibroblast Activation in Thyroid Eye Disease Via MAPK/ERK1/2 Pathway.0
383867582024SOX9 switch links regeneration to fibrosis at the single-cell level in mammalian kidneys.2
384862792024Sox9 downregulation in non-obstructive azoospermia by UTF1 and mediator role of POU5F1.0
385663952024SOX9 promotes stemness in the CAL27 cell line of tongue squamous cell carcinoma.0
387258522024E3 ubiquitin ligase BCA2 promotes breast cancer stemness by up-regulation of SOX9 by LPS.0
387295562024SOX9 is regulated by AURKA in response to Helicobacter pylori infection via EIF4E-mediated cap-dependent translation.0
381796982024Sox9 Accelerates Vascular Aging by Regulating Extracellular Matrix Composition and Stiffness.4
382268372024Hypoxia promotes non-small cell lung cancer cell stemness, migration, and invasion via promoting glycolysis by lactylation of SOX9.3
382382882024Sox9 regulates alternative splicing and pancreatic beta cell function.0
382457672024SOX9 gene shows association with adolescent idiopathic scoliosis predisposition in Northwest Indians.0

Citation

Dessen P

SOX9 (SRY-box transcription factor 9)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43993