ENPP3 (ectonucleotide pyrophosphatase/phosphodiesterase 3)

2007-02-01  

Identity

HGNC
ENPP3
LOCATION
6q23.2
LOCUSID
5169
ALIAS
B10,CD203c,NPP3,PD-IBETA,PDNP3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5169
MIM: 602182
HGNC: 3358
Ensembl: ENSG00000154269

Variants:

dbSNP: 5169
ClinVar: 5169
TCGA: ENSG00000154269
COSMIC: ENPP3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000154269ENST00000357639O14638
ENSG00000154269ENST00000358229F8W6H5
ENSG00000154269ENST00000414305O14638
ENSG00000154269ENST00000423831E9PDB4
ENSG00000154269ENST00000427707E7ETI7

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Purine metabolismKEGGko00230
Pyrimidine metabolismKEGGko00240
Starch and sucrose metabolismKEGGko00500
Riboflavin metabolismKEGGko00740
Nicotinate and nicotinamide metabolismKEGGko00760
Pantothenate and CoA biosynthesisKEGGko00770
Purine metabolismKEGGhsa00230
Pyrimidine metabolismKEGGhsa00240
Starch and sucrose metabolismKEGGhsa00500
Riboflavin metabolismKEGGhsa00740
Nicotinate and nicotinamide metabolismKEGGhsa00760
Pantothenate and CoA biosynthesisKEGGhsa00770
Metabolic pathwaysKEGGhsa01100
MetabolismREACTOMER-HSA-1430728
Metabolism of vitamins and cofactorsREACTOMER-HSA-196854
Metabolism of water-soluble vitamins and cofactorsREACTOMER-HSA-196849
Vitamin B5 (pantothenate) metabolismREACTOMER-HSA-199220

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
366117972022Identification of CD203c as a New Basophil-Specific Flow-Marker in Ph(+) Chronic Myeloid Leukemia.1
366117972022Identification of CD203c as a New Basophil-Specific Flow-Marker in Ph(+) Chronic Myeloid Leukemia.1
336741912021Activated steady status and distinctive FcεRI-mediated responsiveness in basophils of atopic dermatitis.5
346505572021Serum CD203c+ Extracellular Vesicle Serves as a Novel Diagnostic and Prognostic Biomarker for Succinylated Gelatin Induced Perioperative Hypersensitive Reaction.2
336741912021Activated steady status and distinctive FcεRI-mediated responsiveness in basophils of atopic dermatitis.5
346505572021Serum CD203c+ Extracellular Vesicle Serves as a Novel Diagnostic and Prognostic Biomarker for Succinylated Gelatin Induced Perioperative Hypersensitive Reaction.2
302888102019Updates on the surface antigens of basophils: CD16 on basophils of patients with respiratory or insect venom allergy and the rejection of CD203c and CD63 externalization decoupling by bisindolylmaleimides.4
302888102019Updates on the surface antigens of basophils: CD16 on basophils of patients with respiratory or insect venom allergy and the rejection of CD203c and CD63 externalization decoupling by bisindolylmaleimides.4
296142402018Expression of ENPP3 in human cyclic endometrium: a novel molecule involved in embryo implantation.8
297022832018Basophil biomarkers as useful predictors for sublingual immunotherapy in allergic rhinitis.18
297175352018Structural basis for nucleotide recognition by the ectoenzyme CD203c.13
298485722018Phase I Trials of Anti-ENPP3 Antibody-Drug Conjugates in Advanced Refractory Renal Cell Carcinomas.30
296142402018Expression of ENPP3 in human cyclic endometrium: a novel molecule involved in embryo implantation.8
297022832018Basophil biomarkers as useful predictors for sublingual immunotherapy in allergic rhinitis.18
297175352018Structural basis for nucleotide recognition by the ectoenzyme CD203c.13

Citation

Dessen P

ENPP3 (ectonucleotide pyrophosphatase/phosphodiesterase 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/44005/css/template-nav.css