SIRT1 is a member of the mammalian sirtuin genes that encode for seven protein lysine modifiers with deacetylase, ADP-ribosyltransferase and other deacylase activities. SIRT1 plays diverse roles in regulating cell proliferation, differentiation, stress response, metabolism, energy homeostasis, aging and cancer. Besides deacetylating histone substrates, SIRT1 regulates functions of an array of non-histone proteins including transcriptional factors for gene regulation, DNA repair machinery elements for reducing catastrophic genome lesions, epigenetic factors for chromatin and gene regulation, nuclear receptors and circadian clock as well as related factors for metabolism, and other cell signaling molecules. SIRT1 is involved in many types of human cancer.
SIRT1 (sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae))
Atlas Genet Cytogenet Oncol Haematol. 2014-12-01
Online version: http://atlasgeneticsoncology.org/gene/44006/sirt1id44006ch10q21
2010-03-01 SIRT1 (sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae)) by Ruo-Chia Tseng,Yi-Ching Wan