ZNF521 (zinc finger protein 521)

2007-06-01  

Identity

HGNC
ZNF521
LOCATION
18q11.2
LOCUSID
25925
ALIAS
EHZF,Evi3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 25925
MIM: 610974
HGNC: 24605
Ensembl: ENSG00000198795

Variants:

dbSNP: 25925
ClinVar: 25925
TCGA: ENSG00000198795
COSMIC: ZNF521

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198795ENST00000361524Q96K83
ENSG00000198795ENST00000399425H7BYU6
ENSG00000198795ENST00000538137Q96K83
ENSG00000198795ENST00000577461J3KT07
ENSG00000198795ENST00000577775J3QQI2
ENSG00000198795ENST00000577801J3KSZ4
ENSG00000198795ENST00000580488J3QRW6
ENSG00000198795ENST00000584787J3KTI4

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
378342022023Zinc Finger 521 Modulates the Nrf2-Notch Signaling Pathway in Human Ovarian Carcinoma.0
378342022023Zinc Finger 521 Modulates the Nrf2-Notch Signaling Pathway in Human Ovarian Carcinoma.0
361910062022Enhanced ZNF521 expression induces an aggressive phenotype in human ovarian carcinoma cell lines.2
361910062022Enhanced ZNF521 expression induces an aggressive phenotype in human ovarian carcinoma cell lines.2
344451642021Regulatory Role of microRNAs Targeting the Transcription Co-Factor ZNF521 in Normal Tissues and Cancers.10
346391542021ZNF521 Enhances MLL-AF9-Dependent Hematopoietic Stem Cell Transformation in Acute Myeloid Leukemias by Altering the Gene Expression Landscape.7
344451642021Regulatory Role of microRNAs Targeting the Transcription Co-Factor ZNF521 in Normal Tissues and Cancers.10
346391542021ZNF521 Enhances MLL-AF9-Dependent Hematopoietic Stem Cell Transformation in Acute Myeloid Leukemias by Altering the Gene Expression Landscape.7
312276972019Reduced subcutaneous adipogenesis in human hypertrophic obesity is linked to senescent precursor cells.68
315260992019Zinc Finger Protein 521, Negatively Regulated by MicroRNA-204-5p, Promotes Proliferation, Motility and Invasion of Gastric Cancer Cells.13
315586982019The stem cell-associated transcription co-factor, ZNF521, interacts with GLI1 and GLI2 and enhances the activity of the Sonic hedgehog pathway.15
312276972019Reduced subcutaneous adipogenesis in human hypertrophic obesity is linked to senescent precursor cells.68
315260992019Zinc Finger Protein 521, Negatively Regulated by MicroRNA-204-5p, Promotes Proliferation, Motility and Invasion of Gastric Cancer Cells.13
315586982019The stem cell-associated transcription co-factor, ZNF521, interacts with GLI1 and GLI2 and enhances the activity of the Sonic hedgehog pathway.15
299383522018ZNF521 Has an Inhibitory Effect on the Adipogenic Differentiation of Human Adipose-Derived Mesenchymal Stem Cells.20

Citation

Dessen P

ZNF521 (zinc finger protein 521)

Atlas Genet Cytogenet Oncol Haematol. 2007-06-01

Online version: http://atlasgeneticsoncology.org/gene/44033/favicon/tumors-explorer/css/card-gene.css