NECTIN4 (poliovirus receptor-related 4)
2008-01-01 Marc Lopez AffiliationCentre de Recherches en Cancérologie de Marseille, Inserm UMR599, 27 bvd Leiroure,13009 Marseille, France
Identity
HGNC
LOCATION
1q23.3
LOCUSID
ALIAS
EDSS1,LNIR,PRR4,PVRL4,nectin-4
FUSION GENES
DNA/RNA
Description
The PVRL4 gene spans 17.85 kb, consists of 9 exons and 8 introns.
Transcription
The human Nectin-4 mRNA consists of 1458 or 1533 bases (alternative splice forms).
Proteins
Note
Nectin-4 belongs to the family of adhesion molecules: Nectins. Four members have been described ( Nectin-1, Nectin-2, Nectin-3 and Nectin-4). Nectins belong to the immunoglobulin superfamily and exhibit three Ig-like domain in their extracellular region.
Extracellular region of dimeric Nectin-4 is composed with three Ig domains of Ig V and IgC types. The last 4 aminoacids in the C-terminus region binds to the scaffold F-actin binding protein AF-6/afadin. Nectin-4 ectodomain is shedded from cell surface by the metalloprotease TACE/ ADAM-17.
Description
Nectin-4 protein is 510 aminoacid long. Molecular weight is 66 kDa.
Expression
Nectin-4 expression in mainly expressed during development. In mice Nectin-4 transcript are detected at day 11 d.p.c. In human Nectin-4 is not expressed in adult tissues.
Localisation
Nectin-4 is expressed at epithelial adherens junctions. In tumors Nectin-4 expression can be observed in the cytoplasm.
Function
Nectin-4 binds Nectin-1 through IgV domain interaction. Nectin-1 is involved in development. Nectin-4 increases tumor cell migration.
Homology
With other members of the family.
Implicated in
Entity name
Breast carcinoma of basal subtypes.
Disease
Nectin-4 is found in breast tumors and its expression correlates with the basal subtype. The soluble form is detected in sera of patients with metastatic breast carcinoma and is a marker of disease progression.
Prognosis
Adverse prognosis.
Oncogenesis
Related to tumor cell migration.
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 12011057 | 2002 | Prominent role of the Ig-like V domain in trans-interactions of nectins. Nectin3 and nectin 4 bind to the predicted C-C'-C"-D beta-strands of the nectin1 V domain. | Fabre S et al |
| 17474988 | 2007 | Nectin-4 is a new histological and serological tumor associated marker for breast cancer. | Fabre-Lafay S et al |
| 11544254 | 2001 | Nectin4/PRR4, a new afadin-associated member of the nectin family that trans-interacts with nectin1/PRR1 through V domain interaction. | Reymond N et al |
Other Information
Locus ID:
NCBI: 81607
MIM: 609607
HGNC: 19688
Ensembl: ENSG00000143217
Variants:
dbSNP: 81607
ClinVar: 81607
TCGA: ENSG00000143217
COSMIC: NECTIN4
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000143217 | ENST00000368012 | Q96NY8 |
| ENSG00000143217 | ENST00000368012 | K4PZ75 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA166190121 | enfortumab vedotin | Chemical | LabelAnnotation | associated |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38063270 | 2024 | Expression of PVRL4, a molecular target for cancer treatment, is transcriptionally regulated by FOS. | 1 |
| 38196202 | 2024 | Associations of TACSTD2/TROP2 and NECTIN-4/NECTIN-4 with molecular subtypes, PD-L1 expression, and FGFR3 mutational status in two advanced urothelial bladder cancer cohorts. | 2 |
| 38063270 | 2024 | Expression of PVRL4, a molecular target for cancer treatment, is transcriptionally regulated by FOS. | 1 |
| 38196202 | 2024 | Associations of TACSTD2/TROP2 and NECTIN-4/NECTIN-4 with molecular subtypes, PD-L1 expression, and FGFR3 mutational status in two advanced urothelial bladder cancer cohorts. | 2 |
| 36585180 | 2023 | Immunohistochemical Analysis of HER2, EGFR, and Nectin-4 Expression in Upper Urinary Tract Urothelial Carcinoma. | 2 |
| 36759721 | 2023 | Trop-2 and Nectin-4 immunohistochemical expression in metastatic colorectal cancer: searching for the right population for drugs' development. | 4 |
| 37183149 | 2023 | A novel homozygous nonsense mutation in NECTIN4 gene in a Pakistani family with ectodermal dysplasia syndactyly syndrome 1. | 1 |
| 37829154 | 2023 | A Recurrent Nonsense Mutation in NECTIN4 Underlying Ectodermal Dysplasia-Syndactyly Syndrome with a Novel Phenotype in a Consanguineous Kashmiri Family. | 0 |
| 38062106 | 2023 | Nectin-4 regulates cellular senescence-associated enlargement of cell size. | 0 |
| 36585180 | 2023 | Immunohistochemical Analysis of HER2, EGFR, and Nectin-4 Expression in Upper Urinary Tract Urothelial Carcinoma. | 2 |
| 36759721 | 2023 | Trop-2 and Nectin-4 immunohistochemical expression in metastatic colorectal cancer: searching for the right population for drugs' development. | 4 |
| 37183149 | 2023 | A novel homozygous nonsense mutation in NECTIN4 gene in a Pakistani family with ectodermal dysplasia syndactyly syndrome 1. | 1 |
| 37829154 | 2023 | A Recurrent Nonsense Mutation in NECTIN4 Underlying Ectodermal Dysplasia-Syndactyly Syndrome with a Novel Phenotype in a Consanguineous Kashmiri Family. | 0 |
| 38062106 | 2023 | Nectin-4 regulates cellular senescence-associated enlargement of cell size. | 0 |
| 35256687 | 2022 | Nectin cell adhesion molecule 4 regulates angiogenesis through Src signaling and serves as a novel therapeutic target in angiosarcoma. | 3 |
Citation
Marc Lopez
NECTIN4 (poliovirus receptor-related 4)
Atlas Genet Cytogenet Oncol Haematol. 2008-01-01
Online version: http://atlasgeneticsoncology.org/gene/44141/nectin4
