TSPAN1 (tetraspanin 1)
2008-01-01 David Murray , Peter Doran AffiliationUCD School of Medicine, Medical Sciences, UCD-Mater Clinical Research Centre, Mater Misericordiae University Hospital, Dublin 7, Ireland
Identity
HGNC
LOCATION
1p34.1
LOCUSID
ALIAS
NET1,TM4C,TM4SF
FUSION GENES
DNA/RNA
Description
The TSPAN1 gene is located on chromosome 1 in a 5419 bp sequence (46418799..46424217). The gene contains 10 exons.
Transcription
mRNA: 1297 nucleotides in length.
Proteins
Description
241 amino acids, 26.2 kDa Protein.
The 241 amino acid sequence is:
1 mqcfsfiktm milfnllifl cgaallavgi wvsidgasfl kifgplsssa mqfvnvgyfl
61 iaagvvvfal gflgcygakt eskcalvtff filllifiae vaaavvalvy ttmaehfltl
121 lvvpaikkdy gsqedftqvw nttmkglkcc gftnytdfed spyfkensaf ppfccndnvt
181 ntanetctkq kahdqkvegc fnqllydirt navtvggvaa gigglelaam ivsmylycnl
241 q
The 241 amino acid sequence is:
1 mqcfsfiktm milfnllifl cgaallavgi wvsidgasfl kifgplsssa mqfvnvgyfl
61 iaagvvvfal gflgcygakt eskcalvtff filllifiae vaaavvalvy ttmaehfltl
121 lvvpaikkdy gsqedftqvw nttmkglkcc gftnytdfed spyfkensaf ppfccndnvt
181 ntanetctkq kahdqkvegc fnqllydirt navtvggvaa gigglelaam ivsmylycnl
241 q
Expression
Widely expressed.
Localisation
Plasma Membrane
Function
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. These are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility.
Homology
Holomogy with Pan troglodytes (100%); Canis lupus familiaris (89%); Mus musculus (82%), Rattus norvegicus (82%), Gallus gallus (70%).
Mutations
Note
TSPAN1 is subject to the following misense mutations :
| Source ID | rs2234266 | rs2234267 | rs2234268 | rs1047216 |
| Wild type nucleotide | A | C | G | A |
| Wild type amino acid | M | S | V | K |
| Variant nucleotide | G | T | A | G |
| Variant amino acid | V | F | M | E |
| Amino Acid Position | 0 | 37 | 86 | 188 |
Implicated in
Entity name
Cervical Cancer
Disease
Cervical cancer is a malignant carcinoma or the cervix, typically composed of squamous cells. Most studies have found that human papillomavirus (HPV) infection is responsible for virtually all cases of cervical cancer.
Prognosis
Prognosis depends on the stage of the cancer. The 5 year survival rate with treatment is 80 to 90% in patients with stage I disease and 50 to 65% in patients with stage II disease. 25 to 35% of women with stage III cancer and 15% or fewer of those with stage IV cancer are alive after 5 years. Prognosis drops dramatically with tumour metastasis. Thirty-five percent of patients with invasive cervical cancer have persistent or recurrent disease after treatment.
Entity name
Hepatocellular Carcinoma
Disease
Hepatocellular Carcinoma (HCC) is a malignancy of the liver. Most cases of HCC are secondary to either a hepatitis B or C infection or cirrhosis.
Prognosis
The prognosis of HCC is dependent on many factors, including tumour size, tumour staging, the involvement of liver vessels, the presence of extrahepatic metastases and the vascularisation of the tumor.
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 17913940 | 2007 | Association of NET-1 gene expression with human hepatocellular carcinoma. | Chen L et al |
| 12115476 | 2002 | Identification of a new proliferation-associated protein NET-1/C4.8 characteristic for a subset of high-grade cervical intraepithelial neoplasia and cervical carcinomas. | Wollscheid V et al |
Other Information
Locus ID:
NCBI: 10103
MIM: 613170
HGNC: 20657
Ensembl: ENSG00000117472
Variants:
dbSNP: 10103
ClinVar: 10103
TCGA: ENSG00000117472
COSMIC: TSPAN1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000117472 | ENST00000372003 | O60635 |
Expression (GTEx)
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38135697 | 2024 | TSPAN1 inhibits metastasis of nasopharyngeal carcinoma via suppressing NF-kB signaling. | 0 |
| 38273746 | 2024 | ALKBH5 Suppresses Autophagy in Prostate Cancer Cells via Inhibiting m6A-Modification of TSPAN1 mRNA. | 0 |
| 38135697 | 2024 | TSPAN1 inhibits metastasis of nasopharyngeal carcinoma via suppressing NF-kB signaling. | 0 |
| 38273746 | 2024 | ALKBH5 Suppresses Autophagy in Prostate Cancer Cells via Inhibiting m6A-Modification of TSPAN1 mRNA. | 0 |
| 36591302 | 2022 | The immunological characteristics of TSPAN1 expressing B cells in autoimmune hepatitis. | 0 |
| 36591302 | 2022 | The immunological characteristics of TSPAN1 expressing B cells in autoimmune hepatitis. | 0 |
| 32972302 | 2021 | TSPAN1 promotes autophagy flux and mediates cooperation between WNT-CTNNB1 signaling and autophagy via the MIR454-FAM83A-TSPAN1 axis in pancreatic cancer. | 40 |
| 33188589 | 2021 | Bioinformatics analysis reveals TSPAN1 as a candidate biomarker of progression and prognosis in pancreatic cancer. | 6 |
| 33320287 | 2021 | miR-573 suppresses pancreatic cancer cell proliferation, migration, and invasion through targeting TSPAN1. | 8 |
| 33331115 | 2021 | Tetraspanin 1 promotes endometriosis leading to ovarian clear cell carcinoma. | 12 |
| 33455017 | 2021 | Prognostic role of TSPAN1, KIAA1324 and ESRP1 in prostate cancer. | 8 |
| 34852709 | 2021 | Tetraspanin 1 (TSPAN1) promotes growth and transferation of breast cancer cells via mediating PI3K/Akt pathway. | 7 |
| 32972302 | 2021 | TSPAN1 promotes autophagy flux and mediates cooperation between WNT-CTNNB1 signaling and autophagy via the MIR454-FAM83A-TSPAN1 axis in pancreatic cancer. | 40 |
| 33188589 | 2021 | Bioinformatics analysis reveals TSPAN1 as a candidate biomarker of progression and prognosis in pancreatic cancer. | 6 |
| 33320287 | 2021 | miR-573 suppresses pancreatic cancer cell proliferation, migration, and invasion through targeting TSPAN1. | 8 |
Citation
David Murray ; Peter Doran
TSPAN1 (tetraspanin 1)
Atlas Genet Cytogenet Oncol Haematol. 2008-01-01
Online version: http://atlasgeneticsoncology.org/gene/44178/tspan1
