2452 bases, starts at 119366147 and ends at 119368598 bp from promoter with minus strand orientation.

This gene contains 2 introns which transcription gives 3 different mRNAs, 2 alternatively spliced variants and 1 unspliced form that encodes good proteins (see figure 1).

The P53CSV protein is involved in programmed cell death. It contains a p53-binding site and it is induced when cells are at low genotoxic stress. It is probably involved in cell survival by interaction between Apaf-1 (apoptosis protease activating factor 1) and heat shock protein 70 (Hsp70) with subsequent inhibition of caspase-9 activation.

This protein contains 76 amino acids and has 8786 (Da) of weight.

The protein is localized in cytoplasm and perinuclear region.

P53CSV is a novel p53-target gene. This gene can modulate apoptotic pathways by interaction with heat shock protein 70 (HSP70), preventing the induction of apoptosis. When cells are submitted to low levels of genotoxic stress, it is an important player in P53-mediated cell survivor pathway (Park and Nakamura, 2005; Felix et al., 2009).
P53CSV can inhibit apoptosis through interaction with APAF1 and HSP70 complex.

There are two identified alterations until now. One of them is located at position 270 of mRNA and the allele G (guanine) is switched to the allele C (cytosine) at position 77 of the amino acid sequence protein. The other one is a synonymous alteration localized at position 160 of mRNA involving the protein residue Leucine. The allele C (cytosine) is switched to the allele T (thymine) at position 40 of the amino acid sequence protein (NCBI).