TYK2 (tyrosine kinase 2)

2003-02-01 Affiliation

Identity

HGNC

TYK2

LOCATION

19p13.2

LOCUSID

7297

ALIAS

IMD35,JTK1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 7297
MIM: 176941
HGNC: 12440
Ensembl: ENSG00000105397

Variants:

dbSNP: 7297
ClinVar: 7297
TCGA: ENSG00000105397
COSMIC: TYK2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000105397	ENST00000264818	P29597
ENSG00000105397	ENST00000264818	A0A024R7E4
ENSG00000105397	ENST00000524462	E9PM19
ENSG00000105397	ENST00000525220	H0YE41
ENSG00000105397	ENST00000525621	P29597
ENSG00000105397	ENST00000525621	A0A024R7E4
ENSG00000105397	ENST00000525976	H0YE24
ENSG00000105397	ENST00000527481	K7EM33
ENSG00000105397	ENST00000529370	E9PPF2
ENSG00000105397	ENST00000530560	K7EJR6
ENSG00000105397	ENST00000530829	E9PQE9
ENSG00000105397	ENST00000531836	E9PQL2
ENSG00000105397	ENST00000533334	H0YCT7

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Jak-STAT signaling pathway	KEGG	ko04630
Jak-STAT signaling pathway	KEGG	hsa04630
NOD-like receptor signaling pathway	KEGG	ko04621
NOD-like receptor signaling pathway	KEGG	hsa04621
Toxoplasmosis	KEGG	ko05145
Toxoplasmosis	KEGG	hsa05145
Hepatitis C	KEGG	ko05160
Hepatitis C	KEGG	hsa05160
Osteoclast differentiation	KEGG	ko04380
Osteoclast differentiation	KEGG	hsa04380
Measles	KEGG	ko05162
Measles	KEGG	hsa05162
Influenza A	KEGG	ko05164
Influenza A	KEGG	hsa05164
Herpes simplex infection	KEGG	ko05168
Herpes simplex infection	KEGG	hsa05168
Epstein-Barr virus infection	KEGG	hsa05169
Epstein-Barr virus infection	KEGG	ko05169
JAK-STAT signaling	KEGG	hsa_M00684
JAK-STAT signaling	KEGG	M00684
Immune System	REACTOME	R-HSA-168256
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Interferon Signaling	REACTOME	R-HSA-913531
Interferon alpha/beta signaling	REACTOME	R-HSA-909733
Regulation of IFNA signaling	REACTOME	R-HSA-912694
Signaling by Interleukins	REACTOME	R-HSA-449147
Interleukin-6 signaling	REACTOME	R-HSA-1059683
Signal Transduction	REACTOME	R-HSA-162582
MAPK family signaling cascades	REACTOME	R-HSA-5683057
MAPK1/MAPK3 signaling	REACTOME	R-HSA-5684996
RAF-independent MAPK1/3 activation	REACTOME	R-HSA-112409
MAPK3 (ERK1) activation	REACTOME	R-HSA-110056
MAPK1 (ERK2) activation	REACTOME	R-HSA-112411
Interleukin-6 family signaling	REACTOME	R-HSA-6783589
IL-6-type cytokine receptor ligand interactions	REACTOME	R-HSA-6788467
Th1 and Th2 cell differentiation	KEGG	ko04658
Th1 and Th2 cell differentiation	KEGG	hsa04658
Th17 cell differentiation	KEGG	ko04659
Th17 cell differentiation	KEGG	hsa04659
Interleukin-4 and 13 signaling	REACTOME	R-HSA-6785807
Interleukin-10 signaling	REACTOME	R-HSA-6783783

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
37950407	2024	Community analysis of large-scale molecular dynamics simulations elucidated dynamics-driven allostery in tyrosine kinase 2.	0
38337161	2024	Associations of genetic variants within TYK2 with pulmonary tuberculosis among Chinese population.	1
37950407	2024	Community analysis of large-scale molecular dynamics simulations elucidated dynamics-driven allostery in tyrosine kinase 2.	0
38337161	2024	Associations of genetic variants within TYK2 with pulmonary tuberculosis among Chinese population.	1
36519621	2023	Clinical Implications of Targeting the JAK-STAT Pathway in Psoriatic Disease: Emphasis on the TYK2 Pathway.	6
36781502	2023	The positive feedback loop of MAD2L1/TYK2/STAT3 induces progression in B-cell acute lymphoblastic leukaemia.	0
36834806	2023	Tyk2 Targeting in Immune-Mediated Inflammatory Diseases.	17
36959416	2023	TYK2 single-nucleotide variants associated with the severity of COVID-19 disease.	2
37860832	2023	Tick-borne flavivirus NS5 antagonizes interferon signaling by inhibiting the catalytic activity of TYK2.	1
37983265	2023	Direct and biologically significant interactions of human herpesvirus 8 interferon regulatory factor 1 with STAT3 and Janus kinase TYK2.	3
36519621	2023	Clinical Implications of Targeting the JAK-STAT Pathway in Psoriatic Disease: Emphasis on the TYK2 Pathway.	6
36781502	2023	The positive feedback loop of MAD2L1/TYK2/STAT3 induces progression in B-cell acute lymphoblastic leukaemia.	0
36834806	2023	Tyk2 Targeting in Immune-Mediated Inflammatory Diseases.	17
36959416	2023	TYK2 single-nucleotide variants associated with the severity of COVID-19 disease.	2
37860832	2023	Tick-borne flavivirus NS5 antagonizes interferon signaling by inhibiting the catalytic activity of TYK2.	1

Citation

Dessen P

TYK2 (tyrosine kinase 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/446/js/js/lib/favicon/favicon-32x32.png