Identity
HGNC
LOCATION
18q21.2
LOCUSID
ALIAS
CDG2T,E2-2,FECD3,ITF-2,ITF2,PTHS,SEF-2,SEF2,SEF2-1,SEF2-1A,SEF2-1B,SEF2-1D,TCF-4,bHLHb19
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 6925
MIM: 602272
HGNC: 11634
Ensembl: ENSG00000196628
Variants:
dbSNP: 6925
ClinVar: 6925
TCGA: ENSG00000196628
COSMIC: TCF4
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Developmental Biology | REACTOME | R-HSA-1266738 |
| Myogenesis | REACTOME | R-HSA-525793 |
| CDO in myogenesis | REACTOME | R-HSA-375170 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37573005 | 2024 | TCF4 Mutations Disrupt Synaptic Function Through Dysregulation of RIMBP2 in Patient-Derived Cortical Neurons. | 1 |
| 38470486 | 2024 | Suppression of TCF4 promotes a ZC3H12A-mediated self-sustaining inflammatory feedback cycle involving IL-17RA/IL-17RE epidermal signaling. | 1 |
| 38571311 | 2024 | DNA methylation episignature and comparative epigenomic profiling for Pitt-Hopkins syndrome caused by TCF4 variants. | 0 |
| 38654332 | 2024 | AMD1 promotes breast cancer aggressiveness via a spermidine-eIF5A hypusination-TCF4 axis. | 2 |
| 38704483 | 2024 | Transcription factor 4 promotes increased corneal endothelial cellular migration by altering microtubules in Fuchs endothelial corneal dystrophy. | 1 |
| 38884552 | 2024 | Dysregulation of the TCF4 Isoform in Corneal Endothelial Cells of Patients With Fuchs Endothelial Corneal Dystrophy. | 0 |
| 37573005 | 2024 | TCF4 Mutations Disrupt Synaptic Function Through Dysregulation of RIMBP2 in Patient-Derived Cortical Neurons. | 1 |
| 38470486 | 2024 | Suppression of TCF4 promotes a ZC3H12A-mediated self-sustaining inflammatory feedback cycle involving IL-17RA/IL-17RE epidermal signaling. | 1 |
| 38571311 | 2024 | DNA methylation episignature and comparative epigenomic profiling for Pitt-Hopkins syndrome caused by TCF4 variants. | 0 |
| 38654332 | 2024 | AMD1 promotes breast cancer aggressiveness via a spermidine-eIF5A hypusination-TCF4 axis. | 2 |
| 38704483 | 2024 | Transcription factor 4 promotes increased corneal endothelial cellular migration by altering microtubules in Fuchs endothelial corneal dystrophy. | 1 |
| 38884552 | 2024 | Dysregulation of the TCF4 Isoform in Corneal Endothelial Cells of Patients With Fuchs Endothelial Corneal Dystrophy. | 0 |
| 37185280 | 2023 | Protein stabilization of ITF2 by NF-κB prevents colitis-associated cancer development. | 2 |
| 37204786 | 2023 | The TCF4 Trinucleotide Repeat Expansion of Fuchs' Endothelial Corneal Dystrophy: Implications for the Anterior Segment of the Eye. | 2 |
| 37863330 | 2023 | USP10 promotes the progression of triple-negative breast cancer by enhancing the stability of TCF4 protein. | 0 |
Citation
Dessen P
TCF4 (transcription factor 4)
Atlas Genet Cytogenet Oncol Haematol. 2004-05-01
Online version: http://atlasgeneticsoncology.org/gene/450/tcf4
