TCF4 (transcription factor 4)

2004-05-01  

Identity

HGNC
TCF4
LOCATION
18q21.2
LOCUSID
6925
ALIAS
CDG2T,E2-2,FECD3,ITF-2,ITF2,PTHS,SEF-2,SEF2,SEF2-1,SEF2-1A,SEF2-1B,SEF2-1D,TCF-4,bHLHb19
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6925
MIM: 602272
HGNC: 11634
Ensembl: ENSG00000196628

Variants:

dbSNP: 6925
ClinVar: 6925
TCGA: ENSG00000196628
COSMIC: TCF4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000196628ENST00000354452P15884
ENSG00000196628ENST00000356073P15884
ENSG00000196628ENST00000356073A0A024R2C0
ENSG00000196628ENST00000398339E9PH57
ENSG00000196628ENST00000457482P15884
ENSG00000196628ENST00000537578P15884
ENSG00000196628ENST00000537856P15884
ENSG00000196628ENST00000540999P15884
ENSG00000196628ENST00000543082P15884
ENSG00000196628ENST00000544241P15884
ENSG00000196628ENST00000561831P15884
ENSG00000196628ENST00000561992P15884
ENSG00000196628ENST00000562030H3BRF7
ENSG00000196628ENST00000562543G0LNT4
ENSG00000196628ENST00000562607H3BNZ2
ENSG00000196628ENST00000562638A0A1B0GXH5
ENSG00000196628ENST00000562847H3BNI2
ENSG00000196628ENST00000563824H3BTC3
ENSG00000196628ENST00000563888H3BUQ3
ENSG00000196628ENST00000564228P15884
ENSG00000196628ENST00000564343H3BMC8
ENSG00000196628ENST00000564403H3BTP3
ENSG00000196628ENST00000564999P15884
ENSG00000196628ENST00000564999A0A024R2C0
ENSG00000196628ENST00000565018P15884
ENSG00000196628ENST00000565124H3BT95
ENSG00000196628ENST00000565393H3BML7
ENSG00000196628ENST00000565908A0A075B723
ENSG00000196628ENST00000566279P15884
ENSG00000196628ENST00000566286P15884
ENSG00000196628ENST00000566514H3BT24
ENSG00000196628ENST00000566777H3BTM9
ENSG00000196628ENST00000567880P15884
ENSG00000196628ENST00000568147H3BP59
ENSG00000196628ENST00000568169H3BTZ0
ENSG00000196628ENST00000568186G0LNT7
ENSG00000196628ENST00000568673P15884
ENSG00000196628ENST00000568740H3BPJ7
ENSG00000196628ENST00000569012H3BPG3
ENSG00000196628ENST00000569357H3BME8
ENSG00000196628ENST00000570146K7ESI6
ENSG00000196628ENST00000570177P15884
ENSG00000196628ENST00000570287P15884
ENSG00000196628ENST00000590810A0A0E3D6N2
ENSG00000196628ENST00000616053P15884
ENSG00000196628ENST00000625925A0A0D9SGE4
ENSG00000196628ENST00000626425A0A0D9SEX8
ENSG00000196628ENST00000626584P15884
ENSG00000196628ENST00000626595A0A0D9SGE5
ENSG00000196628ENST00000626631A0A0D9SGH7
ENSG00000196628ENST00000627320A0A0D9SGJ4
ENSG00000196628ENST00000627685A0A0D9SG61
ENSG00000196628ENST00000627784A0A0D9SG55
ENSG00000196628ENST00000628078A0A0D9SFU5
ENSG00000196628ENST00000628636A0A0D9SEK1
ENSG00000196628ENST00000628689A0A0D9SFZ1
ENSG00000196628ENST00000629343A0A0D9SEZ3
ENSG00000196628ENST00000629387P15884
ENSG00000196628ENST00000630224A0A0D9SG44
ENSG00000196628ENST00000630268A0A0D9SF97
ENSG00000196628ENST00000630319A0A0D9SF18
ENSG00000196628ENST00000630712A0A0D9SGE7
ENSG00000196628ENST00000630720A0A0D9SG78
ENSG00000196628ENST00000630828A0A0D9SFX5
ENSG00000196628ENST00000635822A0A1B0GVB8
ENSG00000196628ENST00000636400P15884
ENSG00000196628ENST00000636751A0A1B0GTP2
ENSG00000196628ENST00000636822A0A1B0GWD5
ENSG00000196628ENST00000637115A0A1B0GUT3
ENSG00000196628ENST00000637169A0A1B0GW91
ENSG00000196628ENST00000637923A0A1B0GV10
ENSG00000196628ENST00000638154A0A1B0GVR6
ENSG00000196628ENST00000643689A0A1B0GWD5

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Developmental BiologyREACTOMER-HSA-1266738
MyogenesisREACTOMER-HSA-525793
CDO in myogenesisREACTOMER-HSA-375170

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
375730052024TCF4 Mutations Disrupt Synaptic Function Through Dysregulation of RIMBP2 in Patient-Derived Cortical Neurons.1
384704862024Suppression of TCF4 promotes a ZC3H12A-mediated self-sustaining inflammatory feedback cycle involving IL-17RA/IL-17RE epidermal signaling.1
385713112024DNA methylation episignature and comparative epigenomic profiling for Pitt-Hopkins syndrome caused by TCF4 variants.0
386543322024AMD1 promotes breast cancer aggressiveness via a spermidine-eIF5A hypusination-TCF4 axis.2
387044832024Transcription factor 4 promotes increased corneal endothelial cellular migration by altering microtubules in Fuchs endothelial corneal dystrophy.1
388845522024Dysregulation of the TCF4 Isoform in Corneal Endothelial Cells of Patients With Fuchs Endothelial Corneal Dystrophy.0
375730052024TCF4 Mutations Disrupt Synaptic Function Through Dysregulation of RIMBP2 in Patient-Derived Cortical Neurons.1
384704862024Suppression of TCF4 promotes a ZC3H12A-mediated self-sustaining inflammatory feedback cycle involving IL-17RA/IL-17RE epidermal signaling.1
385713112024DNA methylation episignature and comparative epigenomic profiling for Pitt-Hopkins syndrome caused by TCF4 variants.0
386543322024AMD1 promotes breast cancer aggressiveness via a spermidine-eIF5A hypusination-TCF4 axis.2
387044832024Transcription factor 4 promotes increased corneal endothelial cellular migration by altering microtubules in Fuchs endothelial corneal dystrophy.1
388845522024Dysregulation of the TCF4 Isoform in Corneal Endothelial Cells of Patients With Fuchs Endothelial Corneal Dystrophy.0
371852802023Protein stabilization of ITF2 by NF-κB prevents colitis-associated cancer development.2
372047862023The TCF4 Trinucleotide Repeat Expansion of Fuchs' Endothelial Corneal Dystrophy: Implications for the Anterior Segment of the Eye.2
378633302023USP10 promotes the progression of triple-negative breast cancer by enhancing the stability of TCF4 protein.0

Citation

Dessen P

TCF4 (transcription factor 4)

Atlas Genet Cytogenet Oncol Haematol. 2004-05-01

Online version: http://atlasgeneticsoncology.org/gene/450/tcf4-(transcription-factor-4)