ZYX (zyxin)

2003-11-01  

Identity

HGNC
ZYX
LOCATION
7q34
LOCUSID
7791
ALIAS
ESP-2,HED-2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7791
MIM: 602002
HGNC: 13200
Ensembl: ENSG00000159840

Variants:

dbSNP: 7791
ClinVar: 7791
TCGA: ENSG00000159840
COSMIC: ZYX

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000159840ENST00000322764Q15942
ENSG00000159840ENST00000354434H0Y2Y8
ENSG00000159840ENST00000392910Q15942
ENSG00000159840ENST00000436448H7C3D3
ENSG00000159840ENST00000446634C9JJK5
ENSG00000159840ENST00000449630H7C3R3
ENSG00000159840ENST00000457235C9IZ41

Expression (GTEx)

0
100
200
300
400
500
600
700
800
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Focal adhesionKEGGko04510
Focal adhesionKEGGhsa04510

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
386051542024Zyxin is important for the stability and function of podocytes, especially during mechanical stretch.0
386051542024Zyxin is important for the stability and function of podocytes, especially during mechanical stretch.0
372159892023Enhancement of Zyxin Promotes Skin Fibrosis by Regulating FAK/PI3K/AKT and TGF-β Signaling Pathways via Integrins.3
375477582023Zyxin promotes hepatocellular carcinoma progression via the activation of AKT/mTOR signaling pathway.2
372159892023Enhancement of Zyxin Promotes Skin Fibrosis by Regulating FAK/PI3K/AKT and TGF-β Signaling Pathways via Integrins.3
375477582023Zyxin promotes hepatocellular carcinoma progression via the activation of AKT/mTOR signaling pathway.2
357409502022Expression of Zyxin in Non-Small Cell Lung Cancer-A Preliminary Study.3
357409502022Expression of Zyxin in Non-Small Cell Lung Cancer-A Preliminary Study.3
338080292021Bioinformatic Analysis of Structure and Function of LIM Domains of Human Zyxin Family Proteins.11
346571462021Essential role of zyxin in platelet biogenesis and glycoprotein Ib-IX surface expression.3
338080292021Bioinformatic Analysis of Structure and Function of LIM Domains of Human Zyxin Family Proteins.11
346571462021Essential role of zyxin in platelet biogenesis and glycoprotein Ib-IX surface expression.3
319492442020Zyxin (ZYX) promotes invasion and acts as a biomarker for aggressive phenotypes of human glioblastoma multiforme.15
323306022020Force-responsive Zyxin modulation in periodontal ligament cells is regulated by YAP rather than TAZ.10
328268802020Cell density-dependent proteolysis by HtrA1 induces translocation of zyxin to the nucleus and increased cell survival.4

Citation

Dessen P

ZYX (zyxin)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/45507