CD40LG (CD40 ligand)

2005-02-01  

Identity

HGNC
LOCATION
Xq26.3
LOCUSID
ALIAS
CD154,CD40L,HIGM1,IGM,IMD3,T-BAM,TNFSF5,TRAP,gp39,hCD40L

Other Information

Locus ID:

NCBI: 959
MIM: 300386
HGNC: 11935
Ensembl: ENSG00000102245

Variants:

dbSNP: 959
ClinVar: 959
TCGA: ENSG00000102245
COSMIC: CD40LG

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000102245ENST00000370628Q3L8U2
ENSG00000102245ENST00000370629P29965

Expression (GTEx)

0
1
2
3
4
5
6

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Cell adhesion molecules (CAMs)KEGGko04514
T cell receptor signaling pathwayKEGGko04660
AsthmaKEGGko05310
Autoimmune thyroid diseaseKEGGko05320
Systemic lupus erythematosusKEGGko05322
Allograft rejectionKEGGko05330
Primary immunodeficiencyKEGGko05340
Cytokine-cytokine receptor interactionKEGGhsa04060
Cell adhesion molecules (CAMs)KEGGhsa04514
T cell receptor signaling pathwayKEGGhsa04660
AsthmaKEGGhsa05310
Autoimmune thyroid diseaseKEGGhsa05320
Systemic lupus erythematosusKEGGhsa05322
Allograft rejectionKEGGhsa05330
Primary immunodeficiencyKEGGhsa05340
Viral myocarditisKEGGhsa05416
Intestinal immune network for IgA productionKEGGko04672
Intestinal immune network for IgA productionKEGGhsa04672
MalariaKEGGko05144
MalariaKEGGhsa05144
ToxoplasmosisKEGGko05145
ToxoplasmosisKEGGhsa05145
NF-kappa B signaling pathwayKEGGhsa04064
NF-kappa B signaling pathwayKEGGko04064
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
TNFR2 non-canonical NF-kB pathwayREACTOMER-HSA-5668541
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathwayREACTOMER-HSA-5676594

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
348429982023Two novel CD40LG gene mutations causing X-linked hyper IgM syndrome in Vietnamese patients.1
374334222023Advanced computational analysis of CD40LG variants in atypical X-linked hyper-IgM syndrome.0
348429982023Two novel CD40LG gene mutations causing X-linked hyper IgM syndrome in Vietnamese patients.1
374334222023Advanced computational analysis of CD40LG variants in atypical X-linked hyper-IgM syndrome.0
350313072022Analysis of physical activity and plasma levels of soluble CD40 and CD40L in older people with gastrointestinal tract cancer.0
356814412022Novel Functions of Integrins as Receptors of CD154: Their Role in Inflammation and Apoptosis.4
358865102022RANTES and CD40L under Conditions of Long-Term Physical Exercise: A Potential Link to Adaptive Immunity.1
360730092022Termination of CD40L co-stimulation promotes human B cell differentiation into antibody-secreting cells.2
364191452022Respiratory infections in X-linked hyper-IgM syndrome with CD40LG mutation: a case series of seven children in China.4
350313072022Analysis of physical activity and plasma levels of soluble CD40 and CD40L in older people with gastrointestinal tract cancer.0
356814412022Novel Functions of Integrins as Receptors of CD154: Their Role in Inflammation and Apoptosis.4
358865102022RANTES and CD40L under Conditions of Long-Term Physical Exercise: A Potential Link to Adaptive Immunity.1
360730092022Termination of CD40L co-stimulation promotes human B cell differentiation into antibody-secreting cells.2
364191452022Respiratory infections in X-linked hyper-IgM syndrome with CD40LG mutation: a case series of seven children in China.4
304476572021Disseminated cryptococcosis in two boys with novel mutation of CD40 Ligand-Associated X-linked hyper-IgM syndrome.4

Citation

Dessen P

CD40LG (CD40 ligand)

Atlas Genet Cytogenet Oncol Haematol. 2005-02-01

Online version: http://atlasgeneticsoncology.org/gene/45508/cancer-prone-explorer/gene-fusions-explorer/css/card-gene.css