CD40LG (CD40 ligand)

2005-02-01  

Identity

HGNC
CD40LG
LOCATION
Xq26.3
LOCUSID
959
ALIAS
CD154,CD40L,HIGM1,IGM,IMD3,T-BAM,TNFSF5,TRAP,gp39,hCD40L

Other Information

Locus ID:

NCBI: 959
MIM: 300386
HGNC: 11935
Ensembl: ENSG00000102245

Variants:

dbSNP: 959
ClinVar: 959
TCGA: ENSG00000102245
COSMIC: CD40LG

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000102245ENST00000370628Q3L8U2
ENSG00000102245ENST00000370629P29965

Expression (GTEx)

0
1
2
3
4
5
6
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Cell adhesion molecules (CAMs)KEGGko04514
T cell receptor signaling pathwayKEGGko04660
AsthmaKEGGko05310
Autoimmune thyroid diseaseKEGGko05320
Systemic lupus erythematosusKEGGko05322
Allograft rejectionKEGGko05330
Primary immunodeficiencyKEGGko05340
Cytokine-cytokine receptor interactionKEGGhsa04060
Cell adhesion molecules (CAMs)KEGGhsa04514
T cell receptor signaling pathwayKEGGhsa04660
AsthmaKEGGhsa05310
Autoimmune thyroid diseaseKEGGhsa05320
Systemic lupus erythematosusKEGGhsa05322
Allograft rejectionKEGGhsa05330
Primary immunodeficiencyKEGGhsa05340
Viral myocarditisKEGGhsa05416
Intestinal immune network for IgA productionKEGGko04672
Intestinal immune network for IgA productionKEGGhsa04672
MalariaKEGGko05144
MalariaKEGGhsa05144
ToxoplasmosisKEGGko05145
ToxoplasmosisKEGGhsa05145
NF-kappa B signaling pathwayKEGGhsa04064
NF-kappa B signaling pathwayKEGGko04064
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
TNFR2 non-canonical NF-kB pathwayREACTOMER-HSA-5668541
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathwayREACTOMER-HSA-5676594

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
348429982023Two novel CD40LG gene mutations causing X-linked hyper IgM syndrome in Vietnamese patients.1
374334222023Advanced computational analysis of CD40LG variants in atypical X-linked hyper-IgM syndrome.0
348429982023Two novel CD40LG gene mutations causing X-linked hyper IgM syndrome in Vietnamese patients.1
374334222023Advanced computational analysis of CD40LG variants in atypical X-linked hyper-IgM syndrome.0
350313072022Analysis of physical activity and plasma levels of soluble CD40 and CD40L in older people with gastrointestinal tract cancer.0
356814412022Novel Functions of Integrins as Receptors of CD154: Their Role in Inflammation and Apoptosis.4
358865102022RANTES and CD40L under Conditions of Long-Term Physical Exercise: A Potential Link to Adaptive Immunity.1
360730092022Termination of CD40L co-stimulation promotes human B cell differentiation into antibody-secreting cells.2
364191452022Respiratory infections in X-linked hyper-IgM syndrome with CD40LG mutation: a case series of seven children in China.4
350313072022Analysis of physical activity and plasma levels of soluble CD40 and CD40L in older people with gastrointestinal tract cancer.0
356814412022Novel Functions of Integrins as Receptors of CD154: Their Role in Inflammation and Apoptosis.4
358865102022RANTES and CD40L under Conditions of Long-Term Physical Exercise: A Potential Link to Adaptive Immunity.1
360730092022Termination of CD40L co-stimulation promotes human B cell differentiation into antibody-secreting cells.2
364191452022Respiratory infections in X-linked hyper-IgM syndrome with CD40LG mutation: a case series of seven children in China.4
304476572021Disseminated cryptococcosis in two boys with novel mutation of CD40 Ligand-Associated X-linked hyper-IgM syndrome.4

Citation

Dessen P

CD40LG (CD40 ligand)

Atlas Genet Cytogenet Oncol Haematol. 2005-02-01

Online version: http://atlasgeneticsoncology.org/gene/45508/cancer-prone-explorer/js/lib/gene-fusions-explorer/