Identity
HGNC
LOCATION
1q23.3
LOCUSID
ALIAS
CD32,CD32A,CDw32,FCG2,FCGR2,FCGR2A1,FcGR,IGFR2
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 2212
MIM: 146790
HGNC: 3616
Ensembl: ENSG00000143226
Variants:
dbSNP: 2212
ClinVar: 2212
TCGA: ENSG00000143226
COSMIC: FCGR2A
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA10004 | adalimumab | Chemical | ClinicalAnnotation | associated | PD | 24048425, 24667440, 25823785, 27044681 | |
| PA10040 | cetuximab | Chemical | ClinicalAnnotation | associated | PD | 23296156, 27897268, 28719596, 30318772 | |
| PA443434 | Arthritis, Rheumatoid | Disease | ClinicalAnnotation | associated | PD | 24667440, 25823785, 30457672 | |
| PA443560 | Breast Neoplasms | Disease | ClinicalAnnotation | associated | PD | 18347005, 21109570 | |
| PA444352 | Head and Neck Neoplasms | Disease | ClinicalAnnotation | associated | PD | 23296156, 27897268, 28719596, 30318772 | |
| PA445451 | Psoriasis | Disease | ClinicalAnnotation | associated | PD | 24048425, 27044681 | |
| PA446108 | Colorectal Neoplasms | Disease | ClinicalAnnotation | associated | PD | 23296156, 27897268, 28719596, 30318772 | |
| PA449515 | etanercept | Chemical | ClinicalAnnotation | associated | PD | 24048425, 27044681 | |
| PA451261 | rituximab | Chemical | ClinicalAnnotation | associated | PD | 30457672 | |
| PA451743 | trastuzumab | Chemical | ClinicalAnnotation | associated | PD | 18347005, 21109570 | |
| PA452639 | infliximab | Chemical | ClinicalAnnotation | associated | PD | 24048425, 24667440, 25823785, 27044681 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38335505 | 2024 | Platelet FcγRIIa expression in patients with stable coronary artery disease. | 0 |
| 38408113 | 2024 | New candidate SNPs for genetic association with Alzheimer's disease: a linkage disequilibrium analysis for the FCGRIIB and PILRA genes. | 0 |
| 38455048 | 2024 | Genetic variation of FcγRIIa induces higher uptake of Leishmania infantum and modulates cytokine production by adherent mononuclear cells in vitro. | 0 |
| 38544414 | 2024 | Regulatory mechanism of FCGR2A in macrophage polarization and its effects on intervertebral disc degeneration. | 0 |
| 38335505 | 2024 | Platelet FcγRIIa expression in patients with stable coronary artery disease. | 0 |
| 38408113 | 2024 | New candidate SNPs for genetic association with Alzheimer's disease: a linkage disequilibrium analysis for the FCGRIIB and PILRA genes. | 0 |
| 38455048 | 2024 | Genetic variation of FcγRIIa induces higher uptake of Leishmania infantum and modulates cytokine production by adherent mononuclear cells in vitro. | 0 |
| 38544414 | 2024 | Regulatory mechanism of FCGR2A in macrophage polarization and its effects on intervertebral disc degeneration. | 0 |
| 37114884 | 2023 | Association between the functional FCGR3A F158V and FCGR2A R131H polymorphisms and responsiveness to biologics in rheumatoid arthritis patients: A meta-analysis. | 1 |
| 37149714 | 2023 | Association between functional FCGR3A F158V and FCGR2A R131H polymorphisms and responsiveness to rituximab in patients with autoimmune diseases: a meta-analysis. | 0 |
| 37174624 | 2023 | Comparative Analysis of FCGR Gene Polymorphism in Pulmonary Sarcoidosis and Tuberculosis. | 3 |
| 38029355 | 2023 | Relationship Between Human FCγRIIA rs1801274 G Allele and Risk of Death Among Different SARS-CoV-2 Variants. | 0 |
| 37114884 | 2023 | Association between the functional FCGR3A F158V and FCGR2A R131H polymorphisms and responsiveness to biologics in rheumatoid arthritis patients: A meta-analysis. | 1 |
| 37149714 | 2023 | Association between functional FCGR3A F158V and FCGR2A R131H polymorphisms and responsiveness to rituximab in patients with autoimmune diseases: a meta-analysis. | 0 |
| 37174624 | 2023 | Comparative Analysis of FCGR Gene Polymorphism in Pulmonary Sarcoidosis and Tuberculosis. | 3 |
Citation
Dessen P
FCGR2A (Fc fragment of IgG receptor IIa)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/45528/fcgr2a
