PADI4 (peptidyl arginine deiminase 4)

2007-02-01  

Identity

HGNC
PADI4
LOCATION
1p36.13
LOCUSID
23569
ALIAS
PAD,PAD4,PADI5,PDI4,PDI5
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23569
MIM: 605347
HGNC: 18368
Ensembl: ENSG00000159339

Variants:

dbSNP: 23569
ClinVar: 23569
TCGA: ENSG00000159339
COSMIC: PADI4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000159339ENST00000375448Q9UM07
ENSG00000159339ENST00000375453B1AQ67

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA166178378uric acidChemicalVariantAnnotationassociatedPK29580174
PA444552HypertensionDiseaseVariantAnnotationassociatedPK29580174

References

Pubmed IDYearTitleCitations
377511152024Polymorphic Analysis of Genes PADI4 (rs2240340, rs1748033) and HLA-DRB1 (rs2395175) in Arthritis Patients in Pakistani Population.0
381510172024hRpn13 shapes the proteome and transcriptome through epigenetic factors HDAC8, PADI4, and transcription factor NF-κB p50.3
377511152024Polymorphic Analysis of Genes PADI4 (rs2240340, rs1748033) and HLA-DRB1 (rs2395175) in Arthritis Patients in Pakistani Population.0
381510172024hRpn13 shapes the proteome and transcriptome through epigenetic factors HDAC8, PADI4, and transcription factor NF-κB p50.3
357027652023The Role of Peptidyl Arginine Deiminase IV(PADI4) in Cancers.1
363723912023The armadillo-repeat domain of Plakophilin 1 binds to human enzyme PADI4.2
365354602023A common missense variant rs874881 of PADI4 gene and rheumatoid arthritis: Genetic association study and in-silico analysis.1
369618842023Neutrophil PAD4: how does it function in cancer beyond promoting NETosis?1
371404452023An African-Specific Variant of TP53 Reveals PADI4 as a Regulator of p53-Mediated Tumor Suppression.5
371450112023PADI4 and IL-33 gene polymorphisms with susceptibility to systemic lupus erythematosus and juvenile idiopathic arthritis, a systematic review and meta-analysis.0
371939922023Implications of Peptidyl Arginine Deiminase 4 gene transcription and polymorphisms in susceptibility to rheumatoid arthritis in an Iranian population.1
374098742023New insights into cancer: MDM2 binds to the citrullinating enzyme PADI4.3
377594582023Molecular Factors in PAD2 (PADI2) and PAD4 (PADI4) Are Associated with Interstitial Lung Disease Susceptibility in Rheumatoid Arthritis Patients.2
357027652023The Role of Peptidyl Arginine Deiminase IV(PADI4) in Cancers.1
363723912023The armadillo-repeat domain of Plakophilin 1 binds to human enzyme PADI4.2

Citation

Dessen P

PADI4 (peptidyl arginine deiminase 4)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45545/gene-fusions-explorer/haematological-explorer/css/lib/dataTables.bootstrap.min.css