CAPN2 (calpain 2)

2007-02-01  

Identity

HGNC
CAPN2
LOCATION
1q41
LOCUSID
824
ALIAS
CANP2,CANPL2,CANPml,mCANP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 824
MIM: 114230
HGNC: 1479
Ensembl: ENSG00000162909

Variants:

dbSNP: 824
ClinVar: 824
TCGA: ENSG00000162909
COSMIC: CAPN2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000162909ENST00000295006P17655
ENSG00000162909ENST00000433674P17655
ENSG00000162909ENST00000434648C9JWY7

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
ApoptosisKEGGko04210
Focal adhesionKEGGko04510
Alzheimer's diseaseKEGGko05010
ApoptosisKEGGhsa04210
Focal adhesionKEGGhsa04510
Alzheimer's diseaseKEGGhsa05010
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141
DiseaseREACTOMER-HSA-1643685
Extracellular matrix organizationREACTOMER-HSA-1474244
Degradation of the extracellular matrixREACTOMER-HSA-1474228
Neurodegenerative DiseasesREACTOMER-HSA-8863678
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease modelsREACTOMER-HSA-8862803

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
376635452023Rare variants in CAPN2 increase risk for isolated hypoplastic left heart syndrome.0
376635452023Rare variants in CAPN2 increase risk for isolated hypoplastic left heart syndrome.0
341912702021Variants in Genes of Calpain System as Modifiers of Spinocerebellar Ataxia Type 3 Phenotype.2
343811172021Cleavage and activation of LIM kinase 1 as a novel mechanism for calpain 2-mediated regulation of nuclear dynamics.4
341912702021Variants in Genes of Calpain System as Modifiers of Spinocerebellar Ataxia Type 3 Phenotype.2
343811172021Cleavage and activation of LIM kinase 1 as a novel mechanism for calpain 2-mediated regulation of nuclear dynamics.4
316803082020CAPN2 acts as an indicator of hepatitis B virus to induce hepatic fibrosis.4
330788302020Calpain-2 participates in the process of calpain-1 inactivation.8
316803082020CAPN2 acts as an indicator of hepatitis B virus to induce hepatic fibrosis.4
330788302020Calpain-2 participates in the process of calpain-1 inactivation.8
304173562019Calpain-2 protects against heat stress-induced cardiomyocyte apoptosis and heart dysfunction by blocking p38 mitogen-activated protein kinase activation.14
304488822019Calpain system protein expression and activity in ovarian cancer.16
316346372019Regulation of calpain 2 expression by miR-223 and miR-145.6
304173562019Calpain-2 protects against heat stress-induced cardiomyocyte apoptosis and heart dysfunction by blocking p38 mitogen-activated protein kinase activation.14
304488822019Calpain system protein expression and activity in ovarian cancer.16

Citation

Dessen P

CAPN2 (calpain 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45566