SUV39H2 (suppressor of variegation 3-9 homolog 2)

2007-02-01  

Identity

HGNC
SUV39H2
LOCATION
10p13
LOCUSID
79723
ALIAS
KMT1B
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 79723
MIM: 606503
HGNC: 17287
Ensembl: ENSG00000152455

Variants:

dbSNP: 79723
ClinVar: 79723
TCGA: ENSG00000152455
COSMIC: SUV39H2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000152455ENST00000313519Q9H5I1
ENSG00000152455ENST00000354919Q9H5I1
ENSG00000152455ENST00000358298H0Y306
ENSG00000152455ENST00000378325Q9H5I1
ENSG00000152455ENST00000378331G5E9A8
ENSG00000152455ENST00000412254C9JMB4
ENSG00000152455ENST00000420416C9IYH9
ENSG00000152455ENST00000433779Q5JSS2

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Lysine degradationKEGGko00310
Lysine degradationKEGGhsa00310
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
PKMTs methylate histone lysinesREACTOMER-HSA-3214841

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
368065572023N6-methyadenosine modified SUV39H2 regulates homologous recombination through epigenetic repression of DUSP6 in gastric cancer.1
368065572023N6-methyadenosine modified SUV39H2 regulates homologous recombination through epigenetic repression of DUSP6 in gastric cancer.1
326910522020Epigenetic hallmarks of age-related macular degeneration are recapitulated in a photosensitive mouse model.6
326910522020Epigenetic hallmarks of age-related macular degeneration are recapitulated in a photosensitive mouse model.6
305427272019Histone methyltransferase SUV39H2 serves oncogenic roles in osteosarcoma.5
307095852019Elevated SUV39H2 attributes to the progression of nasopharyngeal carcinoma via regulation of NRIP1.2
305427272019Histone methyltransferase SUV39H2 serves oncogenic roles in osteosarcoma.5
307095852019Elevated SUV39H2 attributes to the progression of nasopharyngeal carcinoma via regulation of NRIP1.2
294581432018SUV39H2 promotes colorectal cancer proliferation and metastasis via tri-methylation of the SLIT1 promoter.25
303482152018Identification of SUV39H2 as a potential oncogene in lung adenocarcinoma.15
294581432018SUV39H2 promotes colorectal cancer proliferation and metastasis via tri-methylation of the SLIT1 promoter.25
303482152018Identification of SUV39H2 as a potential oncogene in lung adenocarcinoma.15
280420252017Androgen receptor regulation by histone methyltransferase Suppressor of variegation 3-9 homolog 2 and Melanoma antigen-A11.9
283968762017Reduced Histone H3 Lysine 9 Methylation Contributes to the Pathogenesis of Latent Autoimmune Diabetes in Adults via Regulation of SUV39H2 and KDM4C.3
288335052017Aberrant levels of SUV39H1 and SUV39H2 methyltransferase are associated with genomic instability in chronic lymphocytic leukemia.6

Citation

Dessen P

SUV39H2 (suppressor of variegation 3-9 homolog 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45567