SIX3 (SIX homeobox 3)

2007-02-01  

Identity

HGNC
SIX3
LOCATION
2p21
LOCUSID
6496
ALIAS
HPE2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6496
MIM: 603714
HGNC: 10889
Ensembl: ENSG00000138083

Variants:

dbSNP: 6496
ClinVar: 6496
TCGA: ENSG00000138083
COSMIC: SIX3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000138083ENST00000260653O95343

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

References

Pubmed IDYearTitleCitations
359510052023Heterozygous variants in SIX3 and POU1F1 cause pituitary hormone deficiency in mouse and man.2
359510052023Heterozygous variants in SIX3 and POU1F1 cause pituitary hormone deficiency in mouse and man.2
340218612021miR-4306 Suppresses Proliferation of Esophageal Squamous Cell Carcinoma Cell by Targeting SIX3.3
340218612021miR-4306 Suppresses Proliferation of Esophageal Squamous Cell Carcinoma Cell by Targeting SIX3.3
320515532020The EGFR-ZNF263 signaling axis silences SIX3 in glioblastoma epigenetically.13
332641032020TRIM27 acts as an oncogene and regulates cell proliferation and metastasis in non-small cell lung cancer through SIX3-β-catenin signaling.17
320515532020The EGFR-ZNF263 signaling axis silences SIX3 in glioblastoma epigenetically.13
332641032020TRIM27 acts as an oncogene and regulates cell proliferation and metastasis in non-small cell lung cancer through SIX3-β-catenin signaling.17
306727772019Upregulation of sine oculis homeobox homolog 3 is associated with proliferation, invasion, migration, as well as poor prognosis of esophageal cancer.0
306727772019Upregulation of sine oculis homeobox homolog 3 is associated with proliferation, invasion, migration, as well as poor prognosis of esophageal cancer.0
286707352018SIX3 deletions and incomplete penetrance in families affected by holoprosencephaly.7
294639942018The Homeotic Protein SIX3 Suppresses Carcinogenesis and Metastasis through Recruiting the LSD1/NuRD(MTA3) Complex.18
302421532018Discovering human diabetes-risk gene function with genetics and physiological assays.33
286707352018SIX3 deletions and incomplete penetrance in families affected by holoprosencephaly.7
294639942018The Homeotic Protein SIX3 Suppresses Carcinogenesis and Metastasis through Recruiting the LSD1/NuRD(MTA3) Complex.18

Citation

Dessen P

SIX3 (SIX homeobox 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45571